AFN45776.1 protein (Pseudopropionibacterium propionicum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

AFN45776.1

Hypothetical protein. (52 aa)

Predicted Functional Partners:

AFN47262.1

0.568

AFN46782.1

0.403

AFN45196.1

0.403

eccD

0.403

AFN46543.1

0.403

eccCa_2

0.403

Your Current Organism:

Pseudopropionibacterium propionicum

NCBI taxonomy Id: 767029
Other names: P. propionicum F0230a, Propionibacterium propionicum F0230a, Pseudopropionibacterium propionicum F0230a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFN45196.1	AFN45776.1	HMPREF9154_2216	HMPREF9154_2221	Hypothetical protein.	Hypothetical protein.	0.403
AFN45196.1	AFN46543.1	HMPREF9154_2216	HMPREF9154_2218	Hypothetical protein.	Hypothetical protein.	0.777
AFN45196.1	AFN46782.1	HMPREF9154_2216	HMPREF9154_2215	Hypothetical protein.	FHA domain protein.	0.783
AFN45196.1	AFN47262.1	HMPREF9154_2216	HMPREF9154_2220	Hypothetical protein.	Hypothetical protein.	0.531
AFN45196.1	eccCa_2	HMPREF9154_2216	HMPREF9154_2219	Hypothetical protein.	Type VII secretion protein EccCa.	0.789
AFN45196.1	eccD	HMPREF9154_2216	HMPREF9154_2217	Hypothetical protein.	Type VII secretion integral membrane protein EccD.	0.807
AFN45776.1	AFN45196.1	HMPREF9154_2221	HMPREF9154_2216	Hypothetical protein.	Hypothetical protein.	0.403
AFN45776.1	AFN46543.1	HMPREF9154_2221	HMPREF9154_2218	Hypothetical protein.	Hypothetical protein.	0.403
AFN45776.1	AFN46782.1	HMPREF9154_2221	HMPREF9154_2215	Hypothetical protein.	FHA domain protein.	0.403
AFN45776.1	AFN47262.1	HMPREF9154_2221	HMPREF9154_2220	Hypothetical protein.	Hypothetical protein.	0.568
AFN45776.1	eccCa_2	HMPREF9154_2221	HMPREF9154_2219	Hypothetical protein.	Type VII secretion protein EccCa.	0.403
AFN45776.1	eccD	HMPREF9154_2221	HMPREF9154_2217	Hypothetical protein.	Type VII secretion integral membrane protein EccD.	0.403
AFN46543.1	AFN45196.1	HMPREF9154_2218	HMPREF9154_2216	Hypothetical protein.	Hypothetical protein.	0.777
AFN46543.1	AFN45776.1	HMPREF9154_2218	HMPREF9154_2221	Hypothetical protein.	Hypothetical protein.	0.403
AFN46543.1	AFN46782.1	HMPREF9154_2218	HMPREF9154_2215	Hypothetical protein.	FHA domain protein.	0.773
AFN46543.1	AFN47262.1	HMPREF9154_2218	HMPREF9154_2220	Hypothetical protein.	Hypothetical protein.	0.531
AFN46543.1	eccCa_2	HMPREF9154_2218	HMPREF9154_2219	Hypothetical protein.	Type VII secretion protein EccCa.	0.856
AFN46543.1	eccD	HMPREF9154_2218	HMPREF9154_2217	Hypothetical protein.	Type VII secretion integral membrane protein EccD.	0.774
AFN46782.1	AFN45196.1	HMPREF9154_2215	HMPREF9154_2216	FHA domain protein.	Hypothetical protein.	0.783
AFN46782.1	AFN45776.1	HMPREF9154_2215	HMPREF9154_2221	FHA domain protein.	Hypothetical protein.	0.403

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.802

expected number of edges:

11

PPI enrichment p-value:

2.54e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045638

Negative regulation of myeloid cell differentiation

4 of 65

2.05

1.87

0.00019

GO:0045637

Regulation of myeloid cell differentiation

5 of 151

1.78

1.81

0.00012

GO:0045596

Negative regulation of cell differentiation

6 of 451

1.39

0.00019

GO:0007389

Pattern specification process

5 of 328

1.45

1.36

0.00039

GO:0009880

Embryonic pattern specification

3 of 55

2.0

1.34

0.0025

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000978

RNA polymerase II cis-regulatory region sequence-specific DNA binding

9 of 969

1.23

1.66

1.06e-07

GO:0003700

DNA-binding transcription factor activity

10 of 1187

1.19

1.64

1.60e-08

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

5 of 326

1.45

1.52

0.00010

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

9 of 1118

1.17

1.51

1.51e-07

GO:0003677

DNA binding

10 of 2214

0.92

1.0

6.34e-07

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:22829811

(2012) Epigenetic alterations in bladder cancer and their potential clinical implications.

4 of 17

2.64

2.58

1.63e-05

PMID:22495965

(2012) A novel 13 base pair insertion in the sonic hedgehog ZRS limb enhancer (ZRSLMBR1) causes preaxial polydactyly with triphalangeal thumb.

3 of 9

2.79

1.71

0.00076

PMID:26572684

(2015) Transcriptome profiling reveals distinctive traits of retinol metabolism and neonatal parallels in the MRLMpJ mouse.

3 of 11

2.7

1.68

0.00084

PMID:36418415

(2022) The autism-associated Meis2 gene is necessary for cardiac baroreflex regulation in mice.

3 of 13

2.63

1.64

0.00097

PMID:28874668

(2017) Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation.

3 of 19

2.46

1.45

0.0021

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:26589

Embryonic skeletal system morphogenesis, and N-terminal of Homeobox Meis and PKNOX1

6 of 25

2.64

5.58

1.61e-11

CL:26624

Mixed, incl. Protein of unknown function (DUF3528), and N-terminal of Homeobox Meis and PKNOX1

4 of 5

3.17

4.61

3.85e-09

CL:26433

Homeobox, and Neuron fate commitment

7 of 125

2.01

4.2

1.26e-10

CL:32174

Mixed, incl. Adiponectin binding, and G2 nidogen domain and fibulin

2 of 7

2.72

1.24

0.0055

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa05202

Transcriptional misregulation in cancer

4 of 141

1.72

1.63

0.00027

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005634

Nucleus

9 of 3900

0.63

0.4

0.0259

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0371

Homeobox

7 of 203

1.8

3.38

1.55e-09

KW-0238

DNA-binding

8 of 642

1.36

2.01

3.42e-08

KW-0539

Nucleus

8 of 1146

1.11

1.29

2.14e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16493

N-terminal of Homeobox Meis and PKNOX1

2 of 5

2.87

1.04

0.0130

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00389

Homeodomain

7 of 208

1.79

3.25

3.60e-09

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