AFN45148.1 protein (Pseudopropionibacterium propionicum)

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

AFN45148.1

DoxX family protein. (194 aa)

Predicted Functional Partners:

mprA_2

0.791

AFN46506.1

0.786

AFN45404.1

0.596

AFN46855.1

0.548

AFN46231.1

0.478

AFN46585.1

0.424

AFN45189.1

0.407

deoC_2

0.400

Your Current Organism:

Pseudopropionibacterium propionicum

NCBI taxonomy Id: 767029
Other names: P. propionicum F0230a, Propionibacterium propionicum F0230a, Pseudopropionibacterium propionicum F0230a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFN45148.1	AFN45189.1	HMPREF9154_2807	HMPREF9154_1518	DoxX family protein.	Hypothetical protein.	0.407
AFN45148.1	AFN45404.1	HMPREF9154_2807	HMPREF9154_2806	DoxX family protein.	Putative membrane protein.	0.596
AFN45148.1	AFN46231.1	HMPREF9154_2807	HMPREF9154_0379	DoxX family protein.	CpaE-like protein.	0.478
AFN45148.1	AFN46506.1	HMPREF9154_2807	HMPREF9154_2809	DoxX family protein.	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	0.786
AFN45148.1	AFN46585.1	HMPREF9154_2807	HMPREF9154_1688	DoxX family protein.	TIGR03085 family protein.	0.424
AFN45148.1	AFN46855.1	HMPREF9154_2807	HMPREF9154_2077	DoxX family protein.	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	0.548
AFN45148.1	deoC_2	HMPREF9154_2807	HMPREF9154_2810	DoxX family protein.	Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.	0.400
AFN45148.1	mprA_2	HMPREF9154_2807	HMPREF9154_2808	DoxX family protein.	Response regulator MprA.	0.791
AFN45189.1	AFN45148.1	HMPREF9154_1518	HMPREF9154_2807	Hypothetical protein.	DoxX family protein.	0.407
AFN45189.1	AFN46585.1	HMPREF9154_1518	HMPREF9154_1688	Hypothetical protein.	TIGR03085 family protein.	0.452
AFN45404.1	AFN45148.1	HMPREF9154_2806	HMPREF9154_2807	Putative membrane protein.	DoxX family protein.	0.596
AFN45404.1	AFN46506.1	HMPREF9154_2806	HMPREF9154_2809	Putative membrane protein.	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	0.564
AFN45404.1	AFN46585.1	HMPREF9154_2806	HMPREF9154_1688	Putative membrane protein.	TIGR03085 family protein.	0.438
AFN45404.1	mprA_2	HMPREF9154_2806	HMPREF9154_2808	Putative membrane protein.	Response regulator MprA.	0.528
AFN46231.1	AFN45148.1	HMPREF9154_0379	HMPREF9154_2807	CpaE-like protein.	DoxX family protein.	0.478
AFN46506.1	AFN45148.1	HMPREF9154_2809	HMPREF9154_2807	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	DoxX family protein.	0.786
AFN46506.1	AFN45404.1	HMPREF9154_2809	HMPREF9154_2806	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	Putative membrane protein.	0.564
AFN46506.1	deoC_2	HMPREF9154_2809	HMPREF9154_2810	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.	0.413
AFN46506.1	mprA_2	HMPREF9154_2809	HMPREF9154_2808	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	Response regulator MprA.	0.984
AFN46585.1	AFN45148.1	HMPREF9154_1688	HMPREF9154_2807	TIGR03085 family protein.	DoxX family protein.	0.424

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Network Stats

number of nodes:

10

number of edges:

21

average node degree:

4.2

avg. local clustering coefficient:

0.873

expected number of edges:

9

PPI enrichment p-value:

0.000652

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0040019

Positive regulation of embryonic development

2 of 6

2.88

0.81

0.0391

GO:0045039

Protein insertion into mitochondrial inner membrane

2 of 8

2.76

0.8

0.0391

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005743

Mitochondrial inner membrane

4 of 419

1.34

0.72

0.0279

GO:0098798

Mitochondrial protein-containing complex

3 of 267

1.41

0.65

0.0463

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6513

Mixed, incl. Tim10-like, and Mitochondrial intermembrane space import and assembly protein 40

4 of 17

2.73

3.46

5.49e-07

CL:6519

TIM22 mitochondrial import inner membrane insertion complex, and Tim10-like

3 of 5

3.14

2.98

5.61e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1268020

Mitochondrial protein import

3 of 47

2.16

1.47

0.0019

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 5

2.96

1.46

0.0028

GOCC:0098798

Mitochondrial protein complex

4 of 228

1.6

1.2

0.0028

GOCC:0005740

Mitochondrial envelope

4 of 383

1.38

1.05

0.0034

GOCC:0031967

Organelle envelope

5 of 547

1.32

1.03

0.0028

GOCC:0071013

Catalytic step 2 spliceosome

2 of 37

2.09

0.92

0.0215

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

2 of 20

2.36

1.05

0.0132

KW-0496

Mitochondrion

3 of 160

1.63

0.94

0.0132

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10312

Conserved mid region of cactin

2 of 2

3.36

1.51

0.0023

PF04621

PEA3 subfamily ETS-domain transcription factor N terminal domain

2 of 4

3.06

1.45

0.0029

PF02953

Tim10/DDP family zinc finger

2 of 6

2.88

1.39

0.0036

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019134

Splicing factor Cactin, C-terminal

2 of 2

3.36

1.23

0.0073

IPR018816

Splicing factor cactin, central domain

2 of 2

3.36

1.23

0.0073

IPR006715

PEA3-type ETS-domain transcription factor, N-terminal

2 of 4

3.06

1.22

0.0073

IPR035427

Tim10-like domain superfamily

2 of 6

2.88

1.18

0.0085

IPR004217

Tim10-like

2 of 6

2.88

1.18

0.0085

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01050

Cactus-binding C-terminus of cactin protein

2 of 3

3.18

1.65

0.0013

SM00413

Erythroblast transformation specific domain

2 of 32

2.15

0.8

0.0372

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