mprA_2 protein (Pseudopropionibacterium propionicum)

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

mprA_2

Response regulator MprA. (243 aa)

Predicted Functional Partners:

AFN46506.1

0.984

AFN47484.1

0.888

AFN45634.1

0.879

AFN45616.1

0.876

AFN46417.1

0.867

AFN46486.1

0.823

AFN45538.1

0.804

AFN46607.1

0.794

AFN45148.1

0.791

AFN45158.1

0.760

Your Current Organism:

Pseudopropionibacterium propionicum

NCBI taxonomy Id: 767029
Other names: P. propionicum F0230a, Propionibacterium propionicum F0230a, Pseudopropionibacterium propionicum F0230a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFN45148.1	AFN46506.1	HMPREF9154_2807	HMPREF9154_2809	DoxX family protein.	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	0.786
AFN45148.1	mprA_2	HMPREF9154_2807	HMPREF9154_2808	DoxX family protein.	Response regulator MprA.	0.791
AFN45158.1	AFN47484.1	HMPREF9154_0200	HMPREF9154_0321	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	Putative signal transduction histidine-protein kinase/phosphatase MprB.	0.639
AFN45158.1	mprA_2	HMPREF9154_0200	HMPREF9154_2808	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	Response regulator MprA.	0.760
AFN45538.1	AFN47484.1	HMPREF9154_0705	HMPREF9154_0321	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	Putative signal transduction histidine-protein kinase/phosphatase MprB.	0.601
AFN45538.1	mprA_2	HMPREF9154_0705	HMPREF9154_2808	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	Response regulator MprA.	0.804
AFN45616.1	AFN47484.1	HMPREF9154_0548	HMPREF9154_0321	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	Putative signal transduction histidine-protein kinase/phosphatase MprB.	0.659
AFN45616.1	mprA_2	HMPREF9154_0548	HMPREF9154_2808	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	Response regulator MprA.	0.876
AFN45634.1	AFN46486.1	HMPREF9154_0679	HMPREF9154_2265	Putative signal-transduction histidine kinase senX3.	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	0.743
AFN45634.1	AFN47484.1	HMPREF9154_0679	HMPREF9154_0321	Putative signal-transduction histidine kinase senX3.	Putative signal transduction histidine-protein kinase/phosphatase MprB.	0.655
AFN45634.1	mprA_2	HMPREF9154_0679	HMPREF9154_2808	Putative signal-transduction histidine kinase senX3.	Response regulator MprA.	0.879
AFN46417.1	AFN46607.1	HMPREF9154_0615	HMPREF9154_1507	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	0.766
AFN46417.1	AFN47484.1	HMPREF9154_0615	HMPREF9154_0321	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	Putative signal transduction histidine-protein kinase/phosphatase MprB.	0.653
AFN46417.1	mprA_2	HMPREF9154_0615	HMPREF9154_2808	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	Response regulator MprA.	0.867
AFN46486.1	AFN45634.1	HMPREF9154_2265	HMPREF9154_0679	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	Putative signal-transduction histidine kinase senX3.	0.743
AFN46486.1	AFN46607.1	HMPREF9154_2265	HMPREF9154_1507	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	0.760
AFN46486.1	AFN47484.1	HMPREF9154_2265	HMPREF9154_0321	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	Putative signal transduction histidine-protein kinase/phosphatase MprB.	0.656
AFN46486.1	mprA_2	HMPREF9154_2265	HMPREF9154_2808	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	Response regulator MprA.	0.823
AFN46506.1	AFN45148.1	HMPREF9154_2809	HMPREF9154_2807	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	DoxX family protein.	0.786
AFN46506.1	AFN47484.1	HMPREF9154_2809	HMPREF9154_0321	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	Putative signal transduction histidine-protein kinase/phosphatase MprB.	0.653

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

29

PPI enrichment p-value:

3.91e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

4 of 10

1.72

1.59

0.00034

GO:0016070

RNA metabolic process

7 of 91

1.01

0.91

0.00034

GO:0010467

Gene expression

9 of 147

0.91

0.87

5.22e-05

GO:0006353

DNA-templated transcription, termination

2 of 4

1.82

0.8

0.0287

GO:0034654

Nucleobase-containing compound biosynthetic process

5 of 88

0.88

0.58

0.0133

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016779

Nucleotidyltransferase activity

4 of 28

1.28

0.88

0.0066

GO:0003723

RNA binding

6 of 83

0.98

0.75

0.0030

GO:0003676

Nucleic acid binding

9 of 230

0.71

0.57

0.0011

GO:1901363

Heterocyclic compound binding

10 of 446

0.47

0.36

0.0066

GO:0097159

Organic cyclic compound binding

10 of 446

0.47

0.36

0.0066

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:285

Ribosomal small subunit biogenesis, and tRNA pseudouridine synthesis

3 of 5

1.9

1.47

0.0011

CL:110

Ribosome, and Protein transport

7 of 96

0.98

0.9

0.00027

CL:104

Gene expression, and Protein folding

9 of 192

0.79

0.7

0.00019

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03018

RNA degradation

4 of 14

1.58

1.44

0.00047

map03020

RNA polymerase

2 of 4

1.82

0.76

0.0353

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0806

Transcription termination

2 of 3

1.94

0.83

0.0264

KW-0240

DNA-directed RNA polymerase

2 of 4

1.82

0.82

0.0264

KW-0548

Nucleotidyltransferase

3 of 20

1.3

0.7

0.0264

KW-0694

RNA-binding

5 of 63

1.02

0.68

0.0109

KW-0804

Transcription

4 of 45

1.07

0.62

0.0241

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00322

K homology RNA-binding domain

2 of 4

1.82

0.73

0.0402

SM00316

Ribosomal protein S1-like RNA-binding domain

2 of 4

1.82

0.73

0.0402

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