Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
KRV48376.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (117 aa)    
Predicted Functional Partners:
KRV48375.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.773
guaA
GMP synthetase; Catalyzes the synthesis of GMP from XMP.
  
 
  0.661
KRV51492.1
Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.642
KRV49766.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.608
rpsL
30S ribosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
   
   0.570
KRV47845.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.530
KRV50600.1
Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycosyl hydrolase 43 family.
  
     0.514
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
     
  0.488
KRV47519.1
Sugar hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.485
KRV48647.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   0.461
Your Current Organism:
Streptomyces vitaminophilus
NCBI taxonomy Id: 76728
Other names: ATCC 31673, Actinosporangium vitaminiphilum, Actinosporangium vitaminophilum, DSM 41686, IFO 14294, JCM 6054, NBRC 14294, NRRL B-16933, S. vitaminophilus, Streptomyces vitaminiphilus, Streptomyces vitaminophileus, strain SF 2080
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