Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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dusAtRNA dihydrouridine synthase A; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. (346 aa)    
Predicted Functional Partners:
ispH
(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.
 
    0.662
trmJ
RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
  
   
 0.648
AFC86791.1
Hypothetical protein.
       0.642
truB
tRNA pseudouridine 55 synthase; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
  
  
 0.627
AFC86792.1
PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal.
       0.605
AFC86793.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
       0.598
prfC
Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
  
  
 0.584
AFC86789.1
PFAM: Response regulator receiver domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain.
       0.576
AFC86787.1
Methylase of chemotaxis methyl-accepting protein; PFAM: CheR methyltransferase, SAM binding domain; CheR methyltransferase, all-alpha domain.
       0.574
AFC86788.1
Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain; PFAM: CheB methylesterase.
       0.574
Your Current Organism:
Frateuria aurantia
NCBI taxonomy Id: 767434
Other names: F. aurantia DSM 6220, Frateuria aurantia DSM 6220, Frateuria aurantia IFO 3245, Frateuria aurantia str. DSM 6220, Frateuria aurantia strain DSM 6220
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