Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ORW33097.1Isocitrate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (762 aa)    
Predicted Functional Partners:
glcB
Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.
 
 
 0.987
ORW29379.1
Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
   
 
 0.950
kgd
Alpha-ketoglutarate decarboxylase; Kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.898
acnA
Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
   
 
 0.892
ORW29303.1
Isocitrate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 
0.873
sucC
succinate--CoA ligase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
   
 
 0.867
sucD
succinate--CoA ligase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
     
 0.858
ORW32023.1
Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.
     
 0.846
ORW32545.1
FAD-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.842
ORW29445.1
FAD-linked oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.842
Your Current Organism:
Mycobacterium paraense
NCBI taxonomy Id: 767916
Other names: CCUG 66121, DSM 46749, M. paraense, Mycobacterium paraense Fusco da Costa et al. 2015, Mycobacterium sp. FI-10043, Mycobacterium sp. IEC1883, Mycobacterium sp. IEC23, Mycobacterium sp. IEC24, Mycobacterium sp. IEC25, Mycobacterium sp. IEC26, Mycobacterium sp. IEC27, Mycobacterium sp. IEC28, Mycobacterium sp. IEC29, Mycobacterium sp. IEC30, Mycobacterium sp. IEC31, Mycobacterium sp. IEC32, Mycobacterium sp. IEC33, Mycobacterium sp. IEC34, strain IEC26
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