| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| gcvP | guaA-2 | HELO_2526 | HELO_1630 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | 0.547 |
| gcvP | purC | HELO_2526 | HELO_3577 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Phosphoribosylaminoimidazole-succinocarboxamide synthase - Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768),InterPro: SAICAR synthetase,High confidence in function and specificity. | 0.806 |
| gcvP | purD | HELO_2526 | HELO_3502 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Phosphoribosylamine--glycine ligase - Escherichia coli O157:H7,InterPro: Phosphoribosylglycinamide synthetase, High confidence in function and specificity; Belongs to the GARS family. | 0.978 |
| gcvP | purE | HELO_2526 | HELO_1531 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Phosphoribosylaminoimidazole carboxylase,catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.575 |
| gcvP | purF | HELO_2526 | HELO_2244 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.849 |
| gcvP | purH | HELO_2526 | HELO_2176 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Bifunctional purine biosynthesis protein purH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase - Thiomicrospira crunogena (strain XCL-2),InterPro: AICARFT/IMPCHase bienzyme, High confidence in function and specificity. | 0.827 |
| gcvP | purL | HELO_2526 | HELO_1672 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.977 |
| gcvP | purN | HELO_2526 | HELO_2291 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.412 |
| guaA-2 | gcvP | HELO_1630 | HELO_2526 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.547 |
| guaA-2 | purC | HELO_1630 | HELO_3577 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylaminoimidazole-succinocarboxamide synthase - Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768),InterPro: SAICAR synthetase,High confidence in function and specificity. | 0.650 |
| guaA-2 | purD | HELO_1630 | HELO_3502 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylamine--glycine ligase - Escherichia coli O157:H7,InterPro: Phosphoribosylglycinamide synthetase, High confidence in function and specificity; Belongs to the GARS family. | 0.916 |
| guaA-2 | purE | HELO_1630 | HELO_1531 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylaminoimidazole carboxylase,catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.646 |
| guaA-2 | purF | HELO_1630 | HELO_2244 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.782 |
| guaA-2 | purH | HELO_1630 | HELO_2176 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Bifunctional purine biosynthesis protein purH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase - Thiomicrospira crunogena (strain XCL-2),InterPro: AICARFT/IMPCHase bienzyme, High confidence in function and specificity. | 0.863 |
| guaA-2 | purK | HELO_1630 | HELO_1532 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | 0.672 |
| guaA-2 | purL | HELO_1630 | HELO_1672 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.991 |
| guaA-2 | purM | HELO_1630 | HELO_2292 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylaminoimidazole synthetase; Phosphoribosylformylglycinamidine cyclo-ligase -Actinobacillus succinogenes (strain ATCC 55618 / 130Z),InterPro: Phosphoribosylformylglycinamidine cyclo-ligase, High confidence in function and specificity. | 0.643 |
| guaA-2 | purN | HELO_1630 | HELO_2291 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.503 |
| purC | gcvP | HELO_3577 | HELO_2526 | Phosphoribosylaminoimidazole-succinocarboxamide synthase - Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768),InterPro: SAICAR synthetase,High confidence in function and specificity. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.806 |
| purC | guaA-2 | HELO_3577 | HELO_1630 | Phosphoribosylaminoimidazole-succinocarboxamide synthase - Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768),InterPro: SAICAR synthetase,High confidence in function and specificity. | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | 0.650 |