STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purDPhosphoribosylamine--glycine ligase - Escherichia coli O157:H7,InterPro: Phosphoribosylglycinamide synthetase, High confidence in function and specificity; Belongs to the GARS family. (429 aa)    
Predicted Functional Partners:
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
  
 0.999
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 
 0.999
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
 0.998
purM
Phosphoribosylaminoimidazole synthetase; Phosphoribosylformylglycinamidine cyclo-ligase -Actinobacillus succinogenes (strain ATCC 55618 / 130Z),InterPro: Phosphoribosylformylglycinamidine cyclo-ligase, High confidence in function and specificity.
  
 0.998
purE
Phosphoribosylaminoimidazole carboxylase,catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
 0.997
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Bifunctional purine biosynthesis protein purH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase - Thiomicrospira crunogena (strain XCL-2),InterPro: AICARFT/IMPCHase bienzyme, High confidence in function and specificity.
 
 
 0.982
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
  
  
 0.978
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase - Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768),InterPro: SAICAR synthetase,High confidence in function and specificity.
 
 
 0.978
purK
Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
 
  
 0.964
guaA-2
Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP.
 
  
 0.916
Your Current Organism:
Halomonas elongata
NCBI taxonomy Id: 768066
Other names: H. elongata DSM 2581, Halomonas elongata ATCC 33173, Halomonas elongata DSM 2581, Halomonas elongata str. DSM 2581, Halomonas elongata strain DSM 2581
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