| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HELO_4073 | hupB2 | HELO_4073 | HELO_4074 | Putative transposase; Uncharacterized protein yfaD - Escherichia coli (strain K12), Specificity unclear. | K03530 DNA-binding protein HU-beta; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. | 0.773 |
| aroA | hupB2 | HELO_2718 | HELO_4074 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | K03530 DNA-binding protein HU-beta; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. | 0.448 |
| aroA | ihfA | HELO_2718 | HELO_2520 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Integration host factor subunit alpha; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | 0.448 |
| aroA | kefB | HELO_2718 | HELO_3903 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | K03455 monovalent cation:H+ antiporter-2, CPA2 family; Glutathione-regulated potassium-efflux system protein kefB - Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696),InterPro: Sodium/hydrogen exchanger, High confidence in function and specificity; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | 0.518 |
| aroA | pheA | HELO_2718 | HELO_2719 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Chorismate mutase; High confidence in function and specificity. | 0.999 |
| hupB2 | HELO_4073 | HELO_4074 | HELO_4073 | K03530 DNA-binding protein HU-beta; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. | Putative transposase; Uncharacterized protein yfaD - Escherichia coli (strain K12), Specificity unclear. | 0.773 |
| hupB2 | aroA | HELO_4074 | HELO_2718 | K03530 DNA-binding protein HU-beta; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.448 |
| hupB2 | ihfA | HELO_4074 | HELO_2520 | K03530 DNA-binding protein HU-beta; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. | Integration host factor subunit alpha; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | 0.572 |
| hupB2 | kefB | HELO_4074 | HELO_3903 | K03530 DNA-binding protein HU-beta; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. | K03455 monovalent cation:H+ antiporter-2, CPA2 family; Glutathione-regulated potassium-efflux system protein kefB - Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696),InterPro: Sodium/hydrogen exchanger, High confidence in function and specificity; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | 0.503 |
| hupB2 | pheA | HELO_4074 | HELO_2719 | K03530 DNA-binding protein HU-beta; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. | Chorismate mutase; High confidence in function and specificity. | 0.459 |
| hupB2 | polA | HELO_4074 | HELO_4002 | K03530 DNA-binding protein HU-beta; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.406 |
| hupB2 | rpsO | HELO_4074 | HELO_4134 | K03530 DNA-binding protein HU-beta; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. | 30S ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. | 0.481 |
| hupB2 | rpsT | HELO_4074 | HELO_1314 | K03530 DNA-binding protein HU-beta; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. | 30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. | 0.477 |
| ihfA | aroA | HELO_2520 | HELO_2718 | Integration host factor subunit alpha; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.448 |
| ihfA | hupB2 | HELO_2520 | HELO_4074 | Integration host factor subunit alpha; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | K03530 DNA-binding protein HU-beta; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. | 0.572 |
| ihfA | kefB | HELO_2520 | HELO_3903 | Integration host factor subunit alpha; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | K03455 monovalent cation:H+ antiporter-2, CPA2 family; Glutathione-regulated potassium-efflux system protein kefB - Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696),InterPro: Sodium/hydrogen exchanger, High confidence in function and specificity; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | 0.503 |
| ihfA | pheA | HELO_2520 | HELO_2719 | Integration host factor subunit alpha; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | Chorismate mutase; High confidence in function and specificity. | 0.459 |
| ihfA | polA | HELO_2520 | HELO_4002 | Integration host factor subunit alpha; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.509 |
| ihfA | rpsO | HELO_2520 | HELO_4134 | Integration host factor subunit alpha; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | 30S ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. | 0.467 |
| ihfA | rpsT | HELO_2520 | HELO_1314 | Integration host factor subunit alpha; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | 30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. | 0.477 |