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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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experimentally determined
co-expression
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gene co-occurrence
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ADR18113.1Short-chain dehydrogenase/reductase SDR; COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002347: IPR002198; KEGG: hch:HCH_00126 short-chain alcohol dehydrogenase-like protein; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: Short-chain alcohol dehydrogenase-like protein; PFAM: short chain dehydrogenase. (260 aa)    
Predicted Functional Partners:
ADR19132.1
COGs: COG0331 (acyl-carrier-protein) S-malonyltransferase; InterPro IPR014043: IPR004410; KEGG: ddf:DEFDS_0151 [acyl-carrier-protein] S-malonyltransferase; PFAM: Acyl transferase; SPTR: [acyl-carrier-protein] S-malonyltransferase; TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase domain; TIGRFAM: malonyl CoA-acyl carrier protein transacylase.
  
 0.949
ADR19135.1
3-oxoacyl-(acyl-carrier-protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.
  
 0.938
ADR18908.1
Enoyl-(acyl-carrier-protein) reductase (NADH); COGs: COG0623 Enoyl-(acyl-carrier-protein); InterPro IPR002347; KEGG: ddf:DEFDS_1807 enoyl-[acyl-carrier protein] reductase (NADH); SPTR: Enoyl-[acyl-carrier protein] reductase (NADH); PFAM: short chain dehydrogenase.
  
 
 0.927
fabH
3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.
  
 
 0.923
ADR19133.1
3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
  
 
0.922
fabZ
Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
  
 
 0.916
ADR18114.1
2-dehydropantoate 2-reductase; COGs: COG1893 Ketopantoate reductase; InterPro IPR020476: IPR020084: IPR003710: IPR013332: IPR 013752: IPR000086; KEGG: ddf:DEFDS_2126 hypothetical protein; PFAM: Ketopantoate reductase ApbA/PanE domain protein; NUDIX hydrolase; SPTR: 2-dehydropantoate 2-reductase; TIGRFAM: 2-dehydropantoate 2-reductase; PFAM: Ketopantoate reductase PanE/ApbA; NUDIX domain; Ketopantoate reductase PanE/ApbA C terminal; TIGRFAM: 2-dehydropantoate 2-reductase.
     
 0.802
ADR18115.1
ATPase AAA-2 domain protein; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterPro IPR001270: IPR018368: IPR004176: IPR003959: IPR 013093: IPR019489: IPR003593; KEGG: ddf:DEFDS_2127 ATP-dependent Clp protease ATP-binding subunit ClpC; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; Clp domain protein; Clp ATPase-like; SMART: AAA ATPase; SPTR: ATP-dependent Clp protease, ATP-binding subunit ClpC; PFAM: AAA domain (Cdc48 subfamily); Clp amino terminal domain; C-terminal, D2-small domain, of ClpB protein; ATPase family associated with various cel [...]
  
 
 0.775
ADR18263.1
COGs: COG1250 3-hydroxyacyl-CoA dehydrogenase; InterPro IPR017441: IPR006176: IPR006108: IPR001753; KEGG: ddf:DEFDS_1467 3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase; PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; 3-hydroxyacyl-CoA dehydrogenase domain-containing protein; Enoyl-CoA hydratase/isomerase; SPTR: 3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase; PFAM: Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain.
  
 0.723
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 
 0.630
Your Current Organism:
Calditerrivibrio nitroreducens
NCBI taxonomy Id: 768670
Other names: C. nitroreducens DSM 19672, Calditerrivibrio nitroreducens DSM 19672, Calditerrivibrio nitroreducens Yu37-1, Calditerrivibrio nitroreducens str. DSM 19672, Calditerrivibrio nitroreducens strain DSM 19672, Deferribacteraceae bacterium Yu37-1
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