| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADR19875.1 | ADR19878.1 | Calni_1980 | Calni_1983 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | InterPro IPR002541; KEGG: ddf:DEFDS_0808 cytochrome c assembly protein; PFAM: cytochrome c assembly protein; SPTR: Cytochrome c assembly protein; PFAM: Cytochrome C assembly protein. | 0.830 |
| ADR19875.1 | ADR19879.1 | Calni_1980 | Calni_1984 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | MATE efflux family protein; COGs: COG0534 Na+-driven multidrug efflux pump; InterPro IPR002528; KEGG: ddf:DEFDS_0807 multidrug resistance protein, MATE family; PFAM: multi antimicrobial extrusion protein MatE; SPTR: Multidrug resistance protein, MATE family; TIGRFAM: MATE efflux family protein; PFAM: MatE; TIGRFAM: putative efflux protein, MATE family. | 0.556 |
| ADR19875.1 | ADR19880.1 | Calni_1980 | Calni_1985 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | COGs: COG4866 conserved hypothetical protein; KEGG: ddf:DEFDS_0806 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Uncharacterized conserved protein (DUF2156). | 0.621 |
| ADR19875.1 | ADR19881.1 | Calni_1980 | Calni_1986 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR019752: IPR002880; KEGG: ddf:DEFDS_0805 2-oxoacid oxidoreductase gamma-subunit alpha; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; SPTR: 2-oxoacid oxidoreductase, gamma-alpha subunit; PFAM: domain; Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit. | 0.537 |
| ADR19875.1 | ADR19882.1 | Calni_1980 | Calni_1987 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011896: IPR011766; KEGG: ddf:DEFDS_0804 2-oxoacid oxidoreductase subunit beta; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; PRIAM: 2-oxoglutarate synthase; SPTR: 2-oxoacid oxidoreductase, beta subunit; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; PFAM: Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, be [...] | 0.532 |
| ADR19875.1 | ADR19883.1 | Calni_1980 | Calni_1988 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | COGs: COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; InterPro IPR000276: IPR002192; KEGG: dap:Dacet_2177 pyruvate phosphate dikinase PEP/pyruvate-binding protein; PFAM: pyruvate phosphate dikinase PEP/pyruvate-binding; SPTR: Pyruvate phosphate dikinase PEP/pyruvate-binding protein; PFAM: Pyruvate phosphate dikinase, PEP/pyruvate binding domain. | 0.512 |
| ADR19875.1 | ADR19884.1 | Calni_1980 | Calni_1989 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Phosphoglucomutase, alpha-D-glucose phosphate-specific; COGs: COG0033 Phosphoglucomutase; InterPro IPR005852: IPR016066: IPR005844: IPR005845: IPR 005846: IPR005843; KEGG: tra:Trad_0749 phosphoglucomutase, alpha-D-glucose phosphate-specific; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; SPTR: Phosphoglucomutase, alpha-D-glucose phosphate-specific; TIGRFAM: phosphoglucomutase, alpha-D-glucose [...] | 0.497 |
| ADR19875.1 | ADR19885.1 | Calni_1980 | Calni_1990 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Methyltransferase type 11; InterPro IPR013216; KEGG: ddf:DEFDS_0144 hypothetical protein; PFAM: Methyltransferase type 11; SPTR: Putative uncharacterized protein; PFAM: Methyltransferase domain. | 0.567 |
| ADR19875.1 | hemA | Calni_1980 | Calni_1982 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.927 |
| ADR19875.1 | hemC | Calni_1980 | Calni_1981 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.998 |
| ADR19878.1 | ADR19875.1 | Calni_1983 | Calni_1980 | InterPro IPR002541; KEGG: ddf:DEFDS_0808 cytochrome c assembly protein; PFAM: cytochrome c assembly protein; SPTR: Cytochrome c assembly protein; PFAM: Cytochrome C assembly protein. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.830 |
| ADR19878.1 | ADR19879.1 | Calni_1983 | Calni_1984 | InterPro IPR002541; KEGG: ddf:DEFDS_0808 cytochrome c assembly protein; PFAM: cytochrome c assembly protein; SPTR: Cytochrome c assembly protein; PFAM: Cytochrome C assembly protein. | MATE efflux family protein; COGs: COG0534 Na+-driven multidrug efflux pump; InterPro IPR002528; KEGG: ddf:DEFDS_0807 multidrug resistance protein, MATE family; PFAM: multi antimicrobial extrusion protein MatE; SPTR: Multidrug resistance protein, MATE family; TIGRFAM: MATE efflux family protein; PFAM: MatE; TIGRFAM: putative efflux protein, MATE family. | 0.572 |
| ADR19878.1 | ADR19880.1 | Calni_1983 | Calni_1985 | InterPro IPR002541; KEGG: ddf:DEFDS_0808 cytochrome c assembly protein; PFAM: cytochrome c assembly protein; SPTR: Cytochrome c assembly protein; PFAM: Cytochrome C assembly protein. | COGs: COG4866 conserved hypothetical protein; KEGG: ddf:DEFDS_0806 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Uncharacterized conserved protein (DUF2156). | 0.636 |
| ADR19878.1 | ADR19881.1 | Calni_1983 | Calni_1986 | InterPro IPR002541; KEGG: ddf:DEFDS_0808 cytochrome c assembly protein; PFAM: cytochrome c assembly protein; SPTR: Cytochrome c assembly protein; PFAM: Cytochrome C assembly protein. | Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR019752: IPR002880; KEGG: ddf:DEFDS_0805 2-oxoacid oxidoreductase gamma-subunit alpha; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; SPTR: 2-oxoacid oxidoreductase, gamma-alpha subunit; PFAM: domain; Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit. | 0.550 |
| ADR19878.1 | ADR19882.1 | Calni_1983 | Calni_1987 | InterPro IPR002541; KEGG: ddf:DEFDS_0808 cytochrome c assembly protein; PFAM: cytochrome c assembly protein; SPTR: Cytochrome c assembly protein; PFAM: Cytochrome C assembly protein. | COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011896: IPR011766; KEGG: ddf:DEFDS_0804 2-oxoacid oxidoreductase subunit beta; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; PRIAM: 2-oxoglutarate synthase; SPTR: 2-oxoacid oxidoreductase, beta subunit; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; PFAM: Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, be [...] | 0.550 |
| ADR19878.1 | ADR19883.1 | Calni_1983 | Calni_1988 | InterPro IPR002541; KEGG: ddf:DEFDS_0808 cytochrome c assembly protein; PFAM: cytochrome c assembly protein; SPTR: Cytochrome c assembly protein; PFAM: Cytochrome C assembly protein. | COGs: COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; InterPro IPR000276: IPR002192; KEGG: dap:Dacet_2177 pyruvate phosphate dikinase PEP/pyruvate-binding protein; PFAM: pyruvate phosphate dikinase PEP/pyruvate-binding; SPTR: Pyruvate phosphate dikinase PEP/pyruvate-binding protein; PFAM: Pyruvate phosphate dikinase, PEP/pyruvate binding domain. | 0.529 |
| ADR19878.1 | ADR19884.1 | Calni_1983 | Calni_1989 | InterPro IPR002541; KEGG: ddf:DEFDS_0808 cytochrome c assembly protein; PFAM: cytochrome c assembly protein; SPTR: Cytochrome c assembly protein; PFAM: Cytochrome C assembly protein. | Phosphoglucomutase, alpha-D-glucose phosphate-specific; COGs: COG0033 Phosphoglucomutase; InterPro IPR005852: IPR016066: IPR005844: IPR005845: IPR 005846: IPR005843; KEGG: tra:Trad_0749 phosphoglucomutase, alpha-D-glucose phosphate-specific; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; SPTR: Phosphoglucomutase, alpha-D-glucose phosphate-specific; TIGRFAM: phosphoglucomutase, alpha-D-glucose [...] | 0.512 |
| ADR19878.1 | ADR19885.1 | Calni_1983 | Calni_1990 | InterPro IPR002541; KEGG: ddf:DEFDS_0808 cytochrome c assembly protein; PFAM: cytochrome c assembly protein; SPTR: Cytochrome c assembly protein; PFAM: Cytochrome C assembly protein. | Methyltransferase type 11; InterPro IPR013216; KEGG: ddf:DEFDS_0144 hypothetical protein; PFAM: Methyltransferase type 11; SPTR: Putative uncharacterized protein; PFAM: Methyltransferase domain. | 0.497 |
| ADR19878.1 | hemA | Calni_1983 | Calni_1982 | InterPro IPR002541; KEGG: ddf:DEFDS_0808 cytochrome c assembly protein; PFAM: cytochrome c assembly protein; SPTR: Cytochrome c assembly protein; PFAM: Cytochrome C assembly protein. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.850 |
| ADR19878.1 | hemC | Calni_1983 | Calni_1981 | InterPro IPR002541; KEGG: ddf:DEFDS_0808 cytochrome c assembly protein; PFAM: cytochrome c assembly protein; SPTR: Cytochrome c assembly protein; PFAM: Cytochrome C assembly protein. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.805 |