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hisG protein (Thermoproteus tenax) - STRING interaction network
"hisG" - ATP phosphoribosyltransferase in Thermoproteus tenax
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N’-(5’-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (270 aa)    
Predicted Functional Partners:
hisE
Phosphoribosyl-ATP pyrophosphohydrolase (94 aa)
   
 
  0.998
hisF
Imidazole glycerol phosphate synthase, cyclase subunit F; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (255 aa)
 
  0.998
hisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP (147 aa)
 
 
  0.996
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (372 aa)
 
   
  0.996
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit H; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (191 aa)
 
   
  0.995
hisS
histidyl-tRNA synthetase (420 aa)
 
 
  0.986
hisC
Histidinol-phosphate aminotransferase (340 aa)
 
   
  0.979
hisB
Imidazoleglycerol-phosphate dehydratase (181 aa)
 
   
  0.974
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (235 aa)
 
 
  0.950
prsA
Ribose-phosphate pyrophosphokinase (288 aa)
   
 
  0.943
Your Current Organism:
Thermoproteus tenax
NCBI taxonomy Id: 768679
Other names: T. tenax, T. tenax Kra 1, Thermoproteus tenax, Thermoproteus tenax DSM 2078, Thermoproteus tenax JCM 9277, Thermoproteus tenax Kra 1, Thermoproteus tenax str. Kra 1, Thermoproteus tenax strain Kra 1
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