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hisA protein (Thermoproteus tenax) - STRING interaction network
"hisA" - Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase in Thermoproteus tenax
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (235 aa)    
Predicted Functional Partners:
hisF
Imidazole glycerol phosphate synthase, cyclase subunit F; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (255 aa)
 
 
  0.999
hisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP (147 aa)
 
  0.999
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit H; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (191 aa)
 
 
  0.999
hisB
Imidazoleglycerol-phosphate dehydratase (181 aa)
 
   
  0.986
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (372 aa)
 
   
  0.979
hisE
Phosphoribosyl-ATP pyrophosphohydrolase (94 aa)
   
 
  0.956
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N’-(5’-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (270 aa)
 
 
  0.950
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP (510 aa)
         
  0.942
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5’-phosphoribosyl)-anthranilate (PRA) (328 aa)
   
 
  0.925
hisC
Histidinol-phosphate aminotransferase (340 aa)
 
   
  0.918
Your Current Organism:
Thermoproteus tenax
NCBI taxonomy Id: 768679
Other names: T. tenax, T. tenax Kra 1, Thermoproteus tenax, Thermoproteus tenax DSM 2078, Thermoproteus tenax JCM 9277, Thermoproteus tenax Kra 1, Thermoproteus tenax str. Kra 1, Thermoproteus tenax strain Kra 1
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