Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
dnaEDNA polymerase III, alpha subunit. (826 aa)    
Predicted Functional Partners:
dnaN
DNA polymerase III, beta subunit.
    
 0.989
dnaX
DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
  
 0.982
polC
DNA polymerase III, PolC; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
    
 0.937
MSU_0020
Single-stranded DNA-binding protein.
   
 
 0.886
polA2
5'-3' exonuclease, DNA polymerase I like protein.
  
 
 0.859
MSU_0872
Hypothetical protein.
  
 
 0.828
lysS
lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.
       0.716
MSU_0276
5'-3' exonuclease, DNA polymerase I-like protein.
  
 
 0.669
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.653
guaA
GMP synthase.
     
 0.635
Your Current Organism:
Mycoplasma suis
NCBI taxonomy Id: 768700
Other names: M. suis str. Illinois, Mycoplasma suis Illinois, Mycoplasma suis str. Illinois, Mycoplasma suis strain Illinois
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