KAE1 protein (Malassezia pachydermatis) - STRING interaction network

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KAE1

tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (394 aa)

Predicted Functional Partners:

Malapachy_0358

0.999

Malapachy_3826

0.996

Malapachy_4116

0.991

Malapachy_0871

0.846

Malapachy_1666

0.640

Malapachy_1577

0.582

Malapachy_2471

0.519

Malapachy_0567

0.468

Malapachy_3891

0.454

Malapachy_1579

0.445

Your Current Organism:

Malassezia pachydermatis

NCBI taxonomy Id: 77020
Other names: M. pachydermatis, Pityrosporum pachydermatis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KAE1	Malapachy_0358	A0A0M8MPE7	A0A0M9VMU5	tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...]	P53-related protein kinase.	0.999
KAE1	Malapachy_0567	A0A0M8MPE7	A0A0M8MI33	tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...]	O-sialoglycoprotein endopeptidase.	0.468
KAE1	Malapachy_0871	A0A0M8MPE7	A0A0M8MR43	tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...]	Translation factor.	0.846
KAE1	Malapachy_1577	A0A0M8MPE7	A0A0M8MK28	tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...]	Dephospho-kinase.	0.582
KAE1	Malapachy_1579	A0A0M8MPE7	A0A0N0RRZ8	tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...]	Methylase.	0.445
KAE1	Malapachy_1666	A0A0M8MPE7	A0A0M8MS50	tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...]	Ltp1-protein-tyrosine-phosphatase.	0.640
KAE1	Malapachy_2471	A0A0M8MPE7	A0A0M9VQ95	tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...]	Leucine-trna ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.519
KAE1	Malapachy_3826	A0A0M8MPE7	A0A0M8MPV7	tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...]	Uncharacterized protein; Belongs to the CGI121/TPRKB family.	0.996
KAE1	Malapachy_3891	A0A0M8MPE7	A0A0M8MK18	tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...]	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.454
KAE1	Malapachy_4116	A0A0M8MPE7	A0A0M9VP10	tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...]	Uncharacterized protein.	0.991
Malapachy_0358	KAE1	A0A0M9VMU5	A0A0M8MPE7	P53-related protein kinase.	tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...]	0.999
Malapachy_0358	Malapachy_0567	A0A0M9VMU5	A0A0M8MI33	P53-related protein kinase.	O-sialoglycoprotein endopeptidase.	0.990
Malapachy_0358	Malapachy_0871	A0A0M9VMU5	A0A0M8MR43	P53-related protein kinase.	Translation factor.	0.524
Malapachy_0358	Malapachy_3826	A0A0M9VMU5	A0A0M8MPV7	P53-related protein kinase.	Uncharacterized protein; Belongs to the CGI121/TPRKB family.	0.997
Malapachy_0358	Malapachy_4116	A0A0M9VMU5	A0A0M9VP10	P53-related protein kinase.	Uncharacterized protein.	0.910
Malapachy_0567	KAE1	A0A0M8MI33	A0A0M8MPE7	O-sialoglycoprotein endopeptidase.	tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...]	0.468
Malapachy_0567	Malapachy_0358	A0A0M8MI33	A0A0M9VMU5	O-sialoglycoprotein endopeptidase.	P53-related protein kinase.	0.990
Malapachy_0567	Malapachy_0871	A0A0M8MI33	A0A0M8MR43	O-sialoglycoprotein endopeptidase.	Translation factor.	0.845
Malapachy_0567	Malapachy_1577	A0A0M8MI33	A0A0M8MK28	O-sialoglycoprotein endopeptidase.	Dephospho-kinase.	0.582
Malapachy_0567	Malapachy_1579	A0A0M8MI33	A0A0N0RRZ8	O-sialoglycoprotein endopeptidase.	Methylase.	0.445

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