ALG13 protein (Malassezia pachydermatis) - STRING interaction network

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Predicted Interactions

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ALG13

UDP-N-acetylglucosamine transferase subunit ALG13; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. (1879 aa)

Predicted Functional Partners:

Malapachy_0219

0.996

Malapachy_2122

0.910

Malapachy_2450

0.897

Malapachy_2698

0.897

Malapachy_0274

0.897

Malapachy_1132

0.882

Malapachy_3787

0.870

Malapachy_1085

0.853

Malapachy_1851

0.816

Malapachy_3341

0.816

Your Current Organism:

Malassezia pachydermatis

NCBI taxonomy Id: 77020
Other names: M. pachydermatis, Pityrosporum pachydermatis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALG13	Malapachy_0219	A0A0M8MSE8	A0A0M9VNN0	UDP-N-acetylglucosamine transferase subunit ALG13; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.	Rheb gtpase rhb1.	0.996
ALG13	Malapachy_0274	A0A0M8MSE8	A0A0N0RS30	UDP-N-acetylglucosamine transferase subunit ALG13; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.	Spt20 domain-containing protein.	0.897
ALG13	Malapachy_1085	A0A0M8MSE8	A0A0M8MW86	UDP-N-acetylglucosamine transferase subunit ALG13; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.853
ALG13	Malapachy_1132	A0A0M8MSE8	A0A0M8MVC9	UDP-N-acetylglucosamine transferase subunit ALG13; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.882
ALG13	Malapachy_1851	A0A0M8MSE8	A0A0M8MNU7	UDP-N-acetylglucosamine transferase subunit ALG13; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.	Sch9-serine threonine protein kinase.	0.816
ALG13	Malapachy_2122	A0A0M8MSE8	A0A0M8MNP4	UDP-N-acetylglucosamine transferase subunit ALG13; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.	Ras-like protein.	0.910
ALG13	Malapachy_2450	A0A0M8MSE8	A0A0M9VQH5	UDP-N-acetylglucosamine transferase subunit ALG13; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.	Uncharacterized protein.	0.897
ALG13	Malapachy_2698	A0A0M8MSE8	A0A0M9VQQ1	UDP-N-acetylglucosamine transferase subunit ALG13; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.	Heat shock protein 90.	0.897
ALG13	Malapachy_3341	A0A0M8MSE8	A0A0M8MXX1	UDP-N-acetylglucosamine transferase subunit ALG13; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.	Uncharacterized protein.	0.816
ALG13	Malapachy_3787	A0A0M8MSE8	A0A0M8MP10	UDP-N-acetylglucosamine transferase subunit ALG13; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.	Ras-related gtp-binding protein a-like protein.	0.870
Malapachy_0219	ALG13	A0A0M9VNN0	A0A0M8MSE8	Rheb gtpase rhb1.	UDP-N-acetylglucosamine transferase subunit ALG13; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.	0.996
Malapachy_0219	Malapachy_0274	A0A0M9VNN0	A0A0N0RS30	Rheb gtpase rhb1.	Spt20 domain-containing protein.	0.880
Malapachy_0219	Malapachy_1085	A0A0M9VNN0	A0A0M8MW86	Rheb gtpase rhb1.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.787
Malapachy_0219	Malapachy_1132	A0A0M9VNN0	A0A0M8MVC9	Rheb gtpase rhb1.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.974
Malapachy_0219	Malapachy_1851	A0A0M9VNN0	A0A0M8MNU7	Rheb gtpase rhb1.	Sch9-serine threonine protein kinase.	0.821
Malapachy_0219	Malapachy_2450	A0A0M9VNN0	A0A0M9VQH5	Rheb gtpase rhb1.	Uncharacterized protein.	0.880
Malapachy_0219	Malapachy_2698	A0A0M9VNN0	A0A0M9VQQ1	Rheb gtpase rhb1.	Heat shock protein 90.	0.880
Malapachy_0219	Malapachy_3341	A0A0M9VNN0	A0A0M8MXX1	Rheb gtpase rhb1.	Uncharacterized protein.	0.821
Malapachy_0219	Malapachy_3787	A0A0M9VNN0	A0A0M8MP10	Rheb gtpase rhb1.	Ras-related gtp-binding protein a-like protein.	0.810
Malapachy_0274	ALG13	A0A0N0RS30	A0A0M8MSE8	Spt20 domain-containing protein.	UDP-N-acetylglucosamine transferase subunit ALG13; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.	0.897

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Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.87

expected number of edges:

11

PPI enrichment p-value:

4.02e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019646

Aerobic electron transport chain

4 of 5

2.55

2.99

2.36e-06

GO:0022900

Electron transport chain

6 of 73

1.56

2.07

2.86e-06

GO:0009060

Aerobic respiration

5 of 48

1.67

1.98

1.84e-05

GO:0006091

Generation of precursor metabolites and energy

7 of 131

1.38

1.76

2.48e-06

GO:0034775

Glutathione transmembrane transport

2 of 2

2.65

1.3

0.0042

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140359

ABC-type transporter activity

4 of 36

1.69

1.47

0.00063

GO:0015399

Primary active transmembrane transporter activity

5 of 86

1.41

1.27

0.00063

GO:0009055

Electron transfer activity

3 of 45

1.47

0.82

0.0174

GO:0016491

Oxidoreductase activity

7 of 547

0.76

0.53

0.0075

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070069

Cytochrome complex

4 of 4

2.65

3.65

1.34e-07

GO:0005887

Integral component of plasma membrane

3 of 49

1.43

1.06

0.0035

GO:0016021

Integral component of membrane

10 of 869

0.71

0.65

2.13e-05

GO:0005886

Plasma membrane

10 of 1250

0.55

0.46

0.00036

GO:0016020

Membrane

11 of 1776

0.44

0.38

0.00042

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2096

Mixed, incl. Cytochrome complex, and Tripeptide transport

8 of 12

2.47

7.0

2.76e-15

CL:2099

Cytochrome complex, and ABC transporter transmembrane region

7 of 7

2.65

6.86

3.07e-14

CL:1952

Mixed, incl. Oxidative phosphorylation, and Ubiquinone

10 of 84

1.72

4.12

2.46e-14

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

tcu00190

Oxidative phosphorylation

7 of 59

1.72

3.14

2.24e-09

tcu02020

Two-component system

4 of 60

1.47

1.35

0.00050

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070069

Cytochrome complex

4 of 4

2.65

3.47

3.00e-07

GOCC:0043190

ATP-binding cassette (ABC) transporter complex

3 of 45

1.47

0.78

0.0216

GOCC:0005887

Integral component of plasma membrane

3 of 62

1.33

0.74

0.0216

GOCC:0032991

Protein-containing complex

7 of 655

0.68

0.43

0.0216

GOCC:0016020

Membrane

7 of 732

0.63

0.41

0.0216

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-1133

Transmembrane helix

10 of 890

0.7

0.62

7.95e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00664

ABC transporter transmembrane region

3 of 10

2.13

1.47

0.0015

PF02322

Cytochrome bd terminal oxidase subunit II

2 of 2

2.65

1.13

0.0088

PF01654

Cytochrome bd terminal oxidase subunit I

2 of 2

2.65

1.13

0.0088

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039421

Type 1 protein exporter

4 of 13

2.14

2.16

5.41e-05

IPR036640

ABC transporter type 1, transmembrane domain superfamily

4 of 13

2.14

2.16

5.41e-05

IPR011527

ABC transporter type 1, transmembrane domain

4 of 13

2.14

2.16

5.41e-05

IPR014223

ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydC

2 of 2

2.65

1.12

0.0092

IPR003317

Cytochrome ubiquinol oxidase subunit 2

2 of 2

2.65

1.12

0.0092

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00382

ATPases associated with a variety of cellular activities

4 of 135

1.12

0.64

0.0245

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