A0A1W2TNZ5 protein (Rosellinia necatrix) - STRING interaction network

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Predicted Interactions

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A0A1W2TNZ5

Putative metal dependent phosphohydrolase. (125 aa)

Predicted Functional Partners:

A0A1W2TJI5

0.862

SPB1

0.541

A0A1S7UIP8

0.525

A0A1S8A7E5

0.503

A0A1W2TV01

0.452

A0A1S7UHH8

0.451

A0A1W2TEE1

0.438

Your Current Organism:

Rosellinia necatrix

NCBI taxonomy Id: 77044
Other names: R. necatrix

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1S7UHH8	A0A1S7UIP8	A0A1S7UHH8	A0A1S7UIP8	Putative WD domain-containing protein.	Putative ribosomal RNA large subunit methyltransferase j.	0.654
A0A1S7UHH8	A0A1S8A7E5	A0A1S7UHH8	A0A1S8A7E5	Putative WD domain-containing protein.	Putative WD domain-containing protein.	0.756
A0A1S7UHH8	A0A1W2TJI5	A0A1S7UHH8	A0A1W2TJI5	Putative WD domain-containing protein.	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.	0.654
A0A1S7UHH8	A0A1W2TNZ5	A0A1S7UHH8	A0A1W2TNZ5	Putative WD domain-containing protein.	Putative metal dependent phosphohydrolase.	0.451
A0A1S7UHH8	A0A1W2TV01	A0A1S7UHH8	A0A1W2TV01	Putative WD domain-containing protein.	Putative prion formation protein 1.	0.999
A0A1S7UHH8	SPB1	A0A1S7UHH8	A0A1W2TLE2	Putative WD domain-containing protein.	AdoMet-dependent rRNA methyltransferase SPB1; Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.	0.937
A0A1S7UIP8	A0A1S7UHH8	A0A1S7UIP8	A0A1S7UHH8	Putative ribosomal RNA large subunit methyltransferase j.	Putative WD domain-containing protein.	0.654
A0A1S7UIP8	A0A1S8A7E5	A0A1S7UIP8	A0A1S8A7E5	Putative ribosomal RNA large subunit methyltransferase j.	Putative WD domain-containing protein.	0.919
A0A1S7UIP8	A0A1W2TNZ5	A0A1S7UIP8	A0A1W2TNZ5	Putative ribosomal RNA large subunit methyltransferase j.	Putative metal dependent phosphohydrolase.	0.525
A0A1S8A7E5	A0A1S7UHH8	A0A1S8A7E5	A0A1S7UHH8	Putative WD domain-containing protein.	Putative WD domain-containing protein.	0.756
A0A1S8A7E5	A0A1S7UIP8	A0A1S8A7E5	A0A1S7UIP8	Putative WD domain-containing protein.	Putative ribosomal RNA large subunit methyltransferase j.	0.919
A0A1S8A7E5	A0A1W2TJI5	A0A1S8A7E5	A0A1W2TJI5	Putative WD domain-containing protein.	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.	0.980
A0A1S8A7E5	A0A1W2TNZ5	A0A1S8A7E5	A0A1W2TNZ5	Putative WD domain-containing protein.	Putative metal dependent phosphohydrolase.	0.503
A0A1S8A7E5	A0A1W2TV01	A0A1S8A7E5	A0A1W2TV01	Putative WD domain-containing protein.	Putative prion formation protein 1.	0.600
A0A1S8A7E5	SPB1	A0A1S8A7E5	A0A1W2TLE2	Putative WD domain-containing protein.	AdoMet-dependent rRNA methyltransferase SPB1; Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.	0.901
A0A1W2TEE1	A0A1W2TNZ5	A0A1W2TEE1	A0A1W2TNZ5	Putative replication factor A2.	Putative metal dependent phosphohydrolase.	0.438
A0A1W2TJI5	A0A1S7UHH8	A0A1W2TJI5	A0A1S7UHH8	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.	Putative WD domain-containing protein.	0.654
A0A1W2TJI5	A0A1S8A7E5	A0A1W2TJI5	A0A1S8A7E5	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.	Putative WD domain-containing protein.	0.980
A0A1W2TJI5	A0A1W2TNZ5	A0A1W2TJI5	A0A1W2TNZ5	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.	Putative metal dependent phosphohydrolase.	0.862
A0A1W2TNZ5	A0A1S7UHH8	A0A1W2TNZ5	A0A1S7UHH8	Putative metal dependent phosphohydrolase.	Putative WD domain-containing protein.	0.451

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

14

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046653

Tetrahydrofolate metabolic process

8 of 33

2.83

9.02

2.97e-18

GO:0006730

One-carbon metabolic process

8 of 54

2.62

8.18

2.62e-17

GO:0019264

Glycine biosynthetic process from serine

6 of 9

3.27

8.07

1.48e-15

GO:0006565

L-serine catabolic process

6 of 9

3.27

8.07

1.48e-15

GO:0046655

Folic acid metabolic process

6 of 11

3.18

7.92

2.29e-15

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016742

Hydroxymethyl-, formyl- and related transferase activity

7 of 20

2.99

8.45

1.12e-16

GO:0070905

Serine binding

6 of 9

3.27

8.0

1.96e-15

GO:0004372

Glycine hydroxymethyltransferase activity

6 of 9

3.27

8.0

1.96e-15

GO:0030170

Pyridoxal phosphate binding

6 of 98

2.23

4.62

1.47e-10

GO:0016741

Transferase activity, transferring one-carbon groups

8 of 365

1.79

3.8

1.96e-11

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009570

Chloroplast stroma

4 of 558

1.3

0.81

0.0128

GO:0005739

Mitochondrion

5 of 1344

1.02

0.66

0.0128

GO:0005737

Cytoplasm

11 of 10715

0.46

0.35

0.0070

GO:0043231

Intracellular membrane-bounded organelle

10 of 11116

0.4

0.28

0.0404

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:35599880

(2022) Glycine max Homologs of DOESNT MAKE INFECTIONS 1, 2, and 3 Function to Impair Heterodera glycines Parasitism While Also Regulating Mitogen Activated Protein Kinase Expression.

6 of 14

3.08

7.22

3.98e-14

PMID:34557481

(2021) Interkingdom Comparison of Threonine Metabolism for Stem Cell Maintenance in Plants and Animals.

6 of 15

3.05

7.2

3.98e-14

PMID:24957993

(2013) Amino Acid biosynthesis pathways in diatoms.

6 of 127

2.12

3.97

2.31e-09

PMID:35033026

(2022) Transcriptome analysis of Auricularia fibrillifera fruit-body responses to drought stress and rehydration.

2 of 10

2.75

1.26

0.0051

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8212

Mixed, incl. Glycine metabolic process, and De novo IMP biosynthetic process

10 of 67

2.62

10.34

2.17e-22

CL:8266

De novo IMP biosynthetic process, and Serine hydroxymethyltransferase

8 of 22

3.01

10.16

4.59e-20

CL:8213

Serine family amino acid catabolic process, and De novo IMP biosynthetic process

9 of 50

2.7

9.83

1.28e-20

CL:8268

De novo IMP biosynthetic process

3 of 11

2.88

2.74

9.52e-06

CL:8294

One carbon pool by folate

2 of 5

3.05

1.55

0.0016

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ppp00670

One carbon pool by folate

8 of 22

3.01

10.6

6.04e-21

ppp00460

Cyanoamino acid metabolism

6 of 17

3.0

7.78

2.48e-15

ppp00630

Glyoxylate and dicarboxylate metabolism

7 of 97

2.31

6.09

5.59e-14

ppp00260

Glycine, serine and threonine metabolism

6 of 71

2.37

5.55

2.89e-12

ppp01230

Biosynthesis of amino acids

6 of 258

1.81

3.33

3.01e-09

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-196757

Metabolism of folate and pterines

7 of 37

2.72

7.52

2.05e-15

MAP-196849

Metabolism of water-soluble vitamins and cofactors

7 of 177

2.05

4.47

3.32e-11

MAP-196854

Metabolism of vitamins and cofactors

7 of 201

1.99

4.27

5.28e-11

MAP-73817

Purine ribonucleoside monophosphate biosynthesis

4 of 25

2.65

3.94

3.56e-08

MAP-8956320

Nucleotide biosynthesis

4 of 29

2.59

3.83

5.10e-08

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0554

One-carbon metabolism

6 of 15

3.05

7.61

6.33e-15

KW-0663

Pyridoxal phosphate

6 of 64

2.42

5.45

7.60e-12

KW-0808

Transferase

6 of 941

1.25

1.37

3.37e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00464

Serine hydroxymethyltransferase

4 of 7

3.2

4.5

6.46e-09

PF01212

Beta-eliminating lyase

2 of 12

2.67

1.06

0.0118

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019798

Serine hydroxymethyltransferase, pyridoxal phosphate binding site

6 of 7

3.38

7.86

4.35e-15

IPR039429

Serine hydroxymethyltransferase-like domain

6 of 8

3.32

7.84

4.35e-15

IPR001085

Serine hydroxymethyltransferase

6 of 8

3.32

7.84

4.35e-15

IPR015422

Pyridoxal phosphate-dependent transferase, small domain

6 of 83

2.31

4.57

3.64e-10

IPR015424

Pyridoxal phosphate-dependent transferase

6 of 92

2.26

4.44

5.27e-10

(more ...)

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