node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDZ96559.1 | SDZ97183.1 | SAMN05216455_10288 | SAMN05216455_102111 | dCMP deaminase. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.831 |
SDZ96559.1 | SEA51309.1 | SAMN05216455_10288 | SAMN05216455_10823 | dCMP deaminase. | Dihydrofolate reductase. | 0.401 |
SDZ96559.1 | SEA53170.1 | SAMN05216455_10288 | SAMN05216455_108101 | dCMP deaminase. | Thymidine kinase. | 0.905 |
SDZ96559.1 | dut | SAMN05216455_10288 | SAMN05216455_10644 | dCMP deaminase. | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.914 |
SDZ97183.1 | SDZ96559.1 | SAMN05216455_102111 | SAMN05216455_10288 | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | dCMP deaminase. | 0.831 |
SDZ97183.1 | SEA51309.1 | SAMN05216455_102111 | SAMN05216455_10823 | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Dihydrofolate reductase. | 0.843 |
SDZ97183.1 | SEA53170.1 | SAMN05216455_102111 | SAMN05216455_108101 | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Thymidine kinase. | 0.922 |
SDZ97183.1 | dut | SAMN05216455_102111 | SAMN05216455_10644 | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.928 |
SDZ97183.1 | fhs | SAMN05216455_102111 | SAMN05216455_101410 | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.823 |
SDZ97183.1 | fmt | SAMN05216455_102111 | SAMN05216455_102171 | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.852 |
SDZ97183.1 | folD | SAMN05216455_102111 | SAMN05216455_101399 | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.841 |
SDZ97183.1 | glyA | SAMN05216455_102111 | SAMN05216455_102295 | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.876 |
SDZ97183.1 | purH_2 | SAMN05216455_102111 | SAMN05216455_108130 | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.832 |
SDZ97183.1 | sigA | SAMN05216455_102111 | SAMN05216455_102110 | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | RNA polymerase primary sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 0.773 |
SEA51309.1 | SDZ96559.1 | SAMN05216455_10823 | SAMN05216455_10288 | Dihydrofolate reductase. | dCMP deaminase. | 0.401 |
SEA51309.1 | SDZ97183.1 | SAMN05216455_10823 | SAMN05216455_102111 | Dihydrofolate reductase. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.843 |
SEA51309.1 | SEA53170.1 | SAMN05216455_10823 | SAMN05216455_108101 | Dihydrofolate reductase. | Thymidine kinase. | 0.408 |
SEA51309.1 | fhs | SAMN05216455_10823 | SAMN05216455_101410 | Dihydrofolate reductase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.890 |
SEA51309.1 | fmt | SAMN05216455_10823 | SAMN05216455_102171 | Dihydrofolate reductase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.893 |
SEA51309.1 | folD | SAMN05216455_10823 | SAMN05216455_101399 | Dihydrofolate reductase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.400 |