LOC100178481 protein (Ciona intestinalis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

LOC100178481

TNF receptor-associated factor 3. (369 aa)

Predicted Functional Partners:

Q1RPY5_CIOIN

0.723

ikk-epsilon

0.703

r27a

0.631

LOC100185384

0.596

zf(an1)-3

0.571

F6YNL7_CIOIN

0.571

F6SYE0_CIOIN

0.562

Q1RL83_CIOIN

0.559

F6VA41_CIOIN

0.559

LOC100179219

0.559

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6SYE0_CIOIN	F6VA41_CIOIN	ENSCINP00000026311	ENSCINP00000022575	Protein kinase domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.472
F6SYE0_CIOIN	LOC100178481	ENSCINP00000026311	ENSCINP00000001022	Protein kinase domain-containing protein.	TNF receptor-associated factor 3.	0.562
F6SYE0_CIOIN	LOC100179219	ENSCINP00000026311	ENSCINP00000031210	Protein kinase domain-containing protein.	SH3_15 domain-containing protein.	0.473
F6SYE0_CIOIN	LOC100185384	ENSCINP00000026311	ENSCINP00000010307	Protein kinase domain-containing protein.	ubiquitin-60S ribosomal protein L40.	0.462
F6SYE0_CIOIN	Q1RL83_CIOIN	ENSCINP00000026311	ENSCINP00000016438	Protein kinase domain-containing protein.	Zinc finger protein Ci-ZF(ZZ/RING)-1 isoform X2.	0.688
F6SYE0_CIOIN	Q1RPY5_CIOIN	ENSCINP00000026311	ENSCINP00000030768	Protein kinase domain-containing protein.	Zinc finger protein.	0.808
F6SYE0_CIOIN	ikk-epsilon	ENSCINP00000026311	ENSCINP00000011687	Protein kinase domain-containing protein.	ikappaB kinase isoform X1.	0.777
F6SYE0_CIOIN	r27a	ENSCINP00000026311	ENSCINP00000012037	Protein kinase domain-containing protein.	R27a protein isoform X1.	0.502
F6VA41_CIOIN	F6SYE0_CIOIN	ENSCINP00000022575	ENSCINP00000026311	ANK_REP_REGION domain-containing protein.	Protein kinase domain-containing protein.	0.472
F6VA41_CIOIN	F6YNL7_CIOIN	ENSCINP00000022575	ENSCINP00000023412	ANK_REP_REGION domain-containing protein.	Ubiquitin-like domain-containing protein.	0.841
F6VA41_CIOIN	LOC100178481	ENSCINP00000022575	ENSCINP00000001022	ANK_REP_REGION domain-containing protein.	TNF receptor-associated factor 3.	0.559
F6VA41_CIOIN	LOC100185384	ENSCINP00000022575	ENSCINP00000010307	ANK_REP_REGION domain-containing protein.	ubiquitin-60S ribosomal protein L40.	0.944
F6VA41_CIOIN	Q1RPY5_CIOIN	ENSCINP00000022575	ENSCINP00000030768	ANK_REP_REGION domain-containing protein.	Zinc finger protein.	0.559
F6VA41_CIOIN	ikk-epsilon	ENSCINP00000022575	ENSCINP00000011687	ANK_REP_REGION domain-containing protein.	ikappaB kinase isoform X1.	0.756
F6VA41_CIOIN	r27a	ENSCINP00000022575	ENSCINP00000012037	ANK_REP_REGION domain-containing protein.	R27a protein isoform X1.	0.970
F6VA41_CIOIN	zf(an1)-3	ENSCINP00000022575	ENSCINP00000009735	ANK_REP_REGION domain-containing protein.	AN1-type domain-containing protein.	0.841
F6YNL7_CIOIN	F6VA41_CIOIN	ENSCINP00000023412	ENSCINP00000022575	Ubiquitin-like domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.841
F6YNL7_CIOIN	LOC100178481	ENSCINP00000023412	ENSCINP00000001022	Ubiquitin-like domain-containing protein.	TNF receptor-associated factor 3.	0.571
F6YNL7_CIOIN	LOC100179219	ENSCINP00000023412	ENSCINP00000031210	Ubiquitin-like domain-containing protein.	SH3_15 domain-containing protein.	0.841
F6YNL7_CIOIN	LOC100185384	ENSCINP00000023412	ENSCINP00000010307	Ubiquitin-like domain-containing protein.	ubiquitin-60S ribosomal protein L40.	0.998

page 1 of 5

Network Stats

number of nodes:

5

number of edges:

7

average node degree:

2.8

avg. local clustering coefficient:

0.9

expected number of edges:

4

PPI enrichment p-value:

0.148

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000209

Protein polyubiquitination

7 of 225

1.86

3.42

3.18e-09

GO:0016567

Protein ubiquitination

10 of 742

1.49

2.77

4.28e-11

GO:0070534

Protein K63-linked ubiquitination

3 of 33

2.32

1.95

0.00020

GO:0043161

Proteasome-mediated ubiquitin-dependent protein catabolic process

5 of 307

1.58

1.68

8.05e-05

GO:0019941

Modification-dependent protein catabolic process

6 of 608

1.36

1.46

6.65e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019787

Ubiquitin-like protein transferase activity

7 of 511

1.5

2.05

1.17e-06

GO:0004842

Ubiquitin-protein transferase activity

6 of 490

1.45

1.65

3.09e-05

GO:0061659

Ubiquitin-like protein ligase activity

4 of 362

1.41

0.86

0.0117

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10284

Mixed, incl. Ubiquitin-like protein conjugating enzyme activity, and Protein sumoylation

6 of 103

2.13

3.69

1.34e-08

CL:10286

Mixed, incl. Ubiquitin conjugating enzyme activity, and Negative regulation of histone ubiquitination

5 of 60

2.28

3.6

5.82e-08

CL:10288

Mixed, incl. Ubiquitin conjugating enzyme activity, and Ubiquitin-dependent protein catabolic process via the N-end rule pathway

4 of 53

2.24

2.63

6.73e-06

CL:10289

Mixed, incl. Ubiquitin conjugating enzyme activity, and Ubiquitin-activating enzyme E1

3 of 42

2.22

1.67

0.00066

CL:10291

Ubiquitin conjugating enzyme activity, and Ubiquitin-activating enzyme E1

2 of 23

2.3

0.8

0.0346

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

dre04120

Ubiquitin mediated proteolysis

7 of 154

2.02

4.48

1.94e-11

dre04141

Protein processing in endoplasmic reticulum

3 of 197

1.55

1.02

0.0063

dre04137

Mitophagy - animal

2 of 87

1.72

0.74

0.0364

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

DRE-983168

Antigen processing: Ubiquitination & Proteasome degradation

7 of 303

1.73

2.92

1.92e-08

DRE-5696395

Formation of Incision Complex in GG-NER

3 of 42

2.22

1.81

0.00034

DRE-9708530

Regulation of BACH1 activity

2 of 10

2.66

1.45

0.0023

DRE-69052

Switching of origins to a post-replicative state

3 of 82

1.93

1.43

0.0014

DRE-975144

IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

2 of 14

2.52

1.37

0.0030

(more ...)

WikiPathways

pathway

description

count in network

strength

signal

false discovery rate

WP324

Cytoplasmic ribosomal proteins

2 of 78

1.77

0.83

0.0243

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0035370

UBC13-UEV1A complex

2 of 2

3.36

1.55

0.0016

GOCC:1990234

Transferase complex

5 of 805

1.16

0.78

0.0088

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013083

Zinc finger, RING/FYVE/PHD-type

5 of 371

1.49

1.21

0.0016

IPR019954

Ubiquitin conserved site

2 of 7

2.82

1.08

0.0113

IPR019956

Ubiquitin domain

2 of 9

2.71

1.04

0.0130

IPR011332

Zinc-binding ribosomal protein

2 of 9

2.71

1.04

0.0130

IPR001841

Zinc finger, RING-type

4 of 248

1.57

0.98

0.0082

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00212

Ubiquitin-conjugating enzyme E2, catalytic domain homologues

3 of 50

2.14

1.54

0.0011

SM00184

Ring finger

4 of 438

1.32

0.84

0.0108

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