fgf4/5/6 protein (Ciona intestinalis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

fgf4/5/6

Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (229 aa)

Predicted Functional Partners:

Fgf8/17/18

0.811

otx2

0.718

fgfr

0.712

F7BEX9_CIOIN

0.600

H2XYT0_CIOIN

0.557

Bmp2/4

0.552

Hh1

0.551

Pax6

0.536

brachyury

0.535

Cibeta-catenin

0.526

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bmp2/4	Cibeta-catenin	ENSCINP00000031019	ENSCINP00000014417	TGFb_propeptide domain-containing protein.	Uncharacterized protein.	0.498
Bmp2/4	Hh1	ENSCINP00000031019	ENSCINP00000013864	TGFb_propeptide domain-containing protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.584
Bmp2/4	brachyury	ENSCINP00000031019	ENSCINP00000001477	TGFb_propeptide domain-containing protein.	Uncharacterized protein.	0.632
Bmp2/4	fgf4/5/6	ENSCINP00000031019	ENSCINP00000001146	TGFb_propeptide domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.552
Bmp2/4	otx2	ENSCINP00000031019	ENSCINP00000031453	TGFb_propeptide domain-containing protein.	Transcription factor protein.	0.601
Cibeta-catenin	Bmp2/4	ENSCINP00000014417	ENSCINP00000031019	Uncharacterized protein.	TGFb_propeptide domain-containing protein.	0.498
Cibeta-catenin	Fgf8/17/18	ENSCINP00000014417	ENSCINP00000018902	Uncharacterized protein.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.520
Cibeta-catenin	brachyury	ENSCINP00000014417	ENSCINP00000001477	Uncharacterized protein.	Uncharacterized protein.	0.526
Cibeta-catenin	fgf4/5/6	ENSCINP00000014417	ENSCINP00000001146	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.526
Cibeta-catenin	otx2	ENSCINP00000014417	ENSCINP00000031453	Uncharacterized protein.	Transcription factor protein.	0.515
F7BEX9_CIOIN	Fgf8/17/18	ENSCINP00000023002	ENSCINP00000018902	Uncharacterized protein.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.512
F7BEX9_CIOIN	fgf4/5/6	ENSCINP00000023002	ENSCINP00000001146	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.600
Fgf8/17/18	Cibeta-catenin	ENSCINP00000018902	ENSCINP00000014417	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.520
Fgf8/17/18	F7BEX9_CIOIN	ENSCINP00000018902	ENSCINP00000023002	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.512
Fgf8/17/18	Hh1	ENSCINP00000018902	ENSCINP00000013864	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.544
Fgf8/17/18	brachyury	ENSCINP00000018902	ENSCINP00000001477	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.490
Fgf8/17/18	fgf4/5/6	ENSCINP00000018902	ENSCINP00000001146	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.811
Fgf8/17/18	fgfr	ENSCINP00000018902	ENSCINP00000001598	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor; Receptor for basic fibroblast growth factor.	0.685
Fgf8/17/18	otx2	ENSCINP00000018902	ENSCINP00000031453	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Transcription factor protein.	0.587
H2XYT0_CIOIN	fgf4/5/6	ENSCINP00000034814	ENSCINP00000001146	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.557