Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LOC100176656lamin-L(II)-like isoform X1; Belongs to the intermediate filament family. (465 aa)    
Predicted Functional Partners:
LOC100182647
Barrier-to-autointegration factor.
    
 0.892
F7AQ24_CIOIN
Uncharacterized protein.
    
 
 0.839
F6XK10_CIOIN
Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.
      
 0.838
F7AY24_CIOIN
Oxysterol-binding protein; Belongs to the OSBP family.
      
 0.838
F6UBT3_CIOIN
Uncharacterized protein; Belongs to the peptidase M16 family.
      
 0.838
zf(rbz)-2
Uncharacterized protein.
    
 
 0.779
LOC100176674
CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.
    
 
 0.754
LOC100186956
Delta(14)-sterol reductase-like.
   
 
 0.718
LOC100187276
Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
      
 0.701
LOC100181221
Integumentary mucin C.1-like.
     
 0.652
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt
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