Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
nodalTransforming growth factor beta superfamily signaling ligand isoform X1. (415 aa)    
Predicted Functional Partners:
Lefty/antivin
TGF_BETA_2 domain-containing protein.
   
 
 0.964
tgfbr-iia
Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    
 0.952
F6U088_CIOIN
Uncharacterized protein.
      
 0.667
H2XTB3_CIOIN
Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
  
 
 0.564
wnt3
Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.
  
 
 
 0.537
LOC100178575
Mothers against decapentaplegic homolog.
  
 
 0.535
tgfbr-ic
Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.
    
 0.533
smad2/3a
Mothers against decapentaplegic homolog.
  
 
 0.519
Tcf/lef
HMG box domain-containing protein.
      
 0.504
H2XKU2_CIOIN
MH1 domain-containing protein.
  
 
 0.486
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt
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