F6ZPY9_CIOIN protein (Ciona intestinalis) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

F6ZPY9_CIOIN

Metallophos domain-containing protein. (385 aa)

Predicted Functional Partners:

F6U128_CIOIN

0.541

F6PN33_CIOIN

0.537

H2Y1J2_CIOIN

0.537

LOC100185957

0.537

LOC100177708

0.489

F6Q539_CIOIN

0.488

F7A1W8_CIOIN

0.479

LOC100177361

0.479

LOC100185445

0.479

LOC100183082

0.479

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6PN33_CIOIN	F6ZPY9_CIOIN	ENSCINP00000004763	ENSCINP00000004518	Tyrosine-protein kinase.	Metallophos domain-containing protein.	0.537
F6PN33_CIOIN	LOC100183082	ENSCINP00000004763	ENSCINP00000025896	Tyrosine-protein kinase.	Lipopolysaccharide-binding protein isoform X2.	0.479
F6PN33_CIOIN	LOC100185445	ENSCINP00000004763	ENSCINP00000025890	Tyrosine-protein kinase.	Lipopolysaccharide-binding protein-like.	0.479
F6PN33_CIOIN	LOC100185957	ENSCINP00000004763	ENSCINP00000036544	Tyrosine-protein kinase.	Mucosa-associated lymphoid tissue lymphoma translocation protein 1-like isoform X1.	0.635
F6Q539_CIOIN	F6ZPY9_CIOIN	ENSCINP00000013306	ENSCINP00000004518	DAGKc domain-containing protein.	Metallophos domain-containing protein.	0.488
F6U128_CIOIN	F6ZPY9_CIOIN	ENSCINP00000001652	ENSCINP00000004518	Uncharacterized protein.	Metallophos domain-containing protein.	0.541
F6U128_CIOIN	F7A1W8_CIOIN	ENSCINP00000001652	ENSCINP00000003864	Uncharacterized protein.	GOLD domain-containing protein.	0.489
F6U128_CIOIN	H2Y1J2_CIOIN	ENSCINP00000001652	ENSCINP00000035776	Uncharacterized protein.	Uncharacterized protein.	0.604
F6U128_CIOIN	LOC100177708	ENSCINP00000001652	ENSCINP00000035544	Uncharacterized protein.	EMC1_C domain-containing protein.	0.534
F6ZPY9_CIOIN	F6PN33_CIOIN	ENSCINP00000004518	ENSCINP00000004763	Metallophos domain-containing protein.	Tyrosine-protein kinase.	0.537
F6ZPY9_CIOIN	F6Q539_CIOIN	ENSCINP00000004518	ENSCINP00000013306	Metallophos domain-containing protein.	DAGKc domain-containing protein.	0.488
F6ZPY9_CIOIN	F6U128_CIOIN	ENSCINP00000004518	ENSCINP00000001652	Metallophos domain-containing protein.	Uncharacterized protein.	0.541
F6ZPY9_CIOIN	F7A1W8_CIOIN	ENSCINP00000004518	ENSCINP00000003864	Metallophos domain-containing protein.	GOLD domain-containing protein.	0.479
F6ZPY9_CIOIN	H2Y1J2_CIOIN	ENSCINP00000004518	ENSCINP00000035776	Metallophos domain-containing protein.	Uncharacterized protein.	0.537
F6ZPY9_CIOIN	LOC100177361	ENSCINP00000004518	ENSCINP00000010932	Metallophos domain-containing protein.	Uncharacterized protein.	0.479
F6ZPY9_CIOIN	LOC100177708	ENSCINP00000004518	ENSCINP00000035544	Metallophos domain-containing protein.	EMC1_C domain-containing protein.	0.489
F6ZPY9_CIOIN	LOC100183082	ENSCINP00000004518	ENSCINP00000025896	Metallophos domain-containing protein.	Lipopolysaccharide-binding protein isoform X2.	0.479
F6ZPY9_CIOIN	LOC100185445	ENSCINP00000004518	ENSCINP00000025890	Metallophos domain-containing protein.	Lipopolysaccharide-binding protein-like.	0.479
F6ZPY9_CIOIN	LOC100185957	ENSCINP00000004518	ENSCINP00000036544	Metallophos domain-containing protein.	Mucosa-associated lymphoid tissue lymphoma translocation protein 1-like isoform X1.	0.537
F7A1W8_CIOIN	F6U128_CIOIN	ENSCINP00000003864	ENSCINP00000001652	GOLD domain-containing protein.	Uncharacterized protein.	0.489

page 1 of 3

Network Stats

number of nodes:

7

number of edges:

13

average node degree:

3.71

avg. local clustering coefficient:

0.924

expected number of edges:

6

PPI enrichment p-value:

0.00911

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015986

Proton motive force-driven ATP synthesis

9 of 21

2.89

10.62

2.13e-21

GO:1902600

Proton transmembrane transport

11 of 103

2.29

8.67

9.50e-22

GO:0046034

ATP metabolic process

10 of 92

2.3

8.07

1.05e-19

GO:0042776

Proton motive force-driven mitochondrial ATP synthesis

5 of 11

2.92

5.76

1.73e-11

GO:0007035

Vacuolar acidification

2 of 19

2.28

1.17

0.0067

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015078

Proton transmembrane transporter activity

11 of 104

2.29

8.78

3.44e-22

GO:0046933

Proton-transporting ATP synthase activity, rotational mechanism

4 of 11

2.82

4.12

2.16e-08

GO:0046961

Proton-transporting ATPase activity, rotational mechanism

2 of 28

2.12

0.85

0.0257

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005753

Mitochondrial proton-transporting ATP synthase complex

9 of 15

3.04

11.77

3.05e-23

GO:0016469

Proton-transporting two-sector ATPase complex

11 of 49

2.61

11.67

7.93e-26

GO:0033177

Proton-transporting two-sector ATPase complex, proton-transporting domain

6 of 22

2.7

6.4

3.95e-13

GO:0000276

Mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)

5 of 9

3.01

6.1

4.70e-12

GO:0033178

Proton-transporting two-sector ATPase complex, catalytic domain

4 of 19

2.58

3.94

3.15e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:25925

Formation of ATP by chemiosmotic coupling

9 of 17

2.99

11.09

4.89e-22

CL:25932

Mitochondrial proton-transporting ATP synthase complex

7 of 7

3.26

9.39

4.52e-18

CL:31860

Vacuolar proton-transporting V-type ATPase, V1 domain

2 of 6

2.78

1.37

0.0032

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

11 of 189

2.03

6.87

1.39e-20

map01100

Metabolic pathways

11 of 2959

0.83

0.9

6.98e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-163210

Formation of ATP by chemiosmotic coupling

9 of 19

2.94

11.04

4.23e-22

MAP-8949613

Cristae formation

9 of 30

2.74

10.05

6.48e-21

MAP-1592230

Mitochondrial biogenesis

9 of 54

2.48

8.54

4.82e-19

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

9 of 130

2.1

6.09

6.21e-16

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

9 of 191

1.93

5.06

1.42e-14

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001630

Right ventricle

5 of 133

1.84

3.0

5.70e-08

BTO:0001703

Right atrium

2 of 102

1.55

1.17

0.0025

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016469

Proton-transporting two-sector ATPase complex

11 of 42

2.68

12.19

2.10e-26

GOCC:0045259

Proton-transporting ATP synthase complex

9 of 25

2.82

10.53

1.46e-21

GOCC:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

6 of 15

2.86

6.79

1.36e-13

GOCC:0005753

Mitochondrial proton-transporting ATP synthase complex

5 of 8

3.06

6.09

5.40e-12

GOCC:0000276

Mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)

4 of 4

3.26

5.02

7.24e-10

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0375

Hydrogen ion transport

8 of 25

2.77

9.09

1.19e-18

KW-0066

ATP synthesis

3 of 5

3.04

3.41

5.89e-07

KW-0139

CF(1)

2 of 4

2.96

1.96

0.00028

KW-0496

Mitochondrion

3 of 158

1.54

1.07

0.0046

KW-0999

Mitochondrion inner membrane

2 of 51

1.86

0.9

0.0183

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF05873

ATP synthase D chain, mitochondrial (ATP5H)

2 of 2

3.26

1.36

0.0036

PF00006

ATP synthase alpha/beta family, nucleotide-binding domain

2 of 4

2.96

1.3

0.0045

PF02874

ATP synthase alpha/beta family, beta-barrel domain

2 of 6

2.78

1.24

0.0056

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