LOC100182231 protein (Ciona intestinalis) - STRING interaction network

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Predicted Interactions

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Score

LOC100182231

Phosphoglycerate kinase. (416 aa)

Predicted Functional Partners:

LOC100183090

0.999

LOC100176359

0.999

LOC100186457

0.999

LOC100177203

0.990

F6UI47_CIOIN

0.981

F7AZD3_CIOIN

0.980

LOC100177545

0.951

F6PZE7_CIOIN

0.934

F6V8G3_CIOIN

0.906

LOC100178594

0.828

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6PZE7_CIOIN	F6UI47_CIOIN	ENSCINP00000009557	ENSCINP00000008557	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.993
F6PZE7_CIOIN	F6V8G3_CIOIN	ENSCINP00000009557	ENSCINP00000022815	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	Enolase_C domain-containing protein.	0.924
F6PZE7_CIOIN	F7AZD3_CIOIN	ENSCINP00000009557	ENSCINP00000019213	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.999
F6PZE7_CIOIN	LOC100176359	ENSCINP00000009557	ENSCINP00000016603	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.	0.872
F6PZE7_CIOIN	LOC100177203	ENSCINP00000009557	ENSCINP00000015064	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	Alpha-enolase-like.	0.948
F6PZE7_CIOIN	LOC100177545	ENSCINP00000009557	ENSCINP00000013211	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	Suf domain-containing protein.	0.755
F6PZE7_CIOIN	LOC100178594	ENSCINP00000009557	ENSCINP00000024844	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	Fructose-2,6-bisphosphatase TIGAR-like.	0.976
F6PZE7_CIOIN	LOC100182231	ENSCINP00000009557	ENSCINP00000004580	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	Phosphoglycerate kinase.	0.934
F6PZE7_CIOIN	LOC100183090	ENSCINP00000009557	ENSCINP00000013486	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	Triosephosphate isomerase.	0.983
F6PZE7_CIOIN	LOC100186457	ENSCINP00000009557	ENSCINP00000034531	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	Glyceraldehyde-3-phosphate dehydrogenase.	0.919
F6UI47_CIOIN	F6PZE7_CIOIN	ENSCINP00000008557	ENSCINP00000009557	Pyruvate kinase; Belongs to the pyruvate kinase family.	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	0.993
F6UI47_CIOIN	F6V8G3_CIOIN	ENSCINP00000008557	ENSCINP00000022815	Pyruvate kinase; Belongs to the pyruvate kinase family.	Enolase_C domain-containing protein.	0.996
F6UI47_CIOIN	F7AZD3_CIOIN	ENSCINP00000008557	ENSCINP00000019213	Pyruvate kinase; Belongs to the pyruvate kinase family.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.996
F6UI47_CIOIN	LOC100176359	ENSCINP00000008557	ENSCINP00000016603	Pyruvate kinase; Belongs to the pyruvate kinase family.	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.	0.958
F6UI47_CIOIN	LOC100177203	ENSCINP00000008557	ENSCINP00000015064	Pyruvate kinase; Belongs to the pyruvate kinase family.	Alpha-enolase-like.	0.997
F6UI47_CIOIN	LOC100177545	ENSCINP00000008557	ENSCINP00000013211	Pyruvate kinase; Belongs to the pyruvate kinase family.	Suf domain-containing protein.	0.846
F6UI47_CIOIN	LOC100178594	ENSCINP00000008557	ENSCINP00000024844	Pyruvate kinase; Belongs to the pyruvate kinase family.	Fructose-2,6-bisphosphatase TIGAR-like.	0.881
F6UI47_CIOIN	LOC100182231	ENSCINP00000008557	ENSCINP00000004580	Pyruvate kinase; Belongs to the pyruvate kinase family.	Phosphoglycerate kinase.	0.981
F6UI47_CIOIN	LOC100183090	ENSCINP00000008557	ENSCINP00000013486	Pyruvate kinase; Belongs to the pyruvate kinase family.	Triosephosphate isomerase.	0.986
F6UI47_CIOIN	LOC100186457	ENSCINP00000008557	ENSCINP00000034531	Pyruvate kinase; Belongs to the pyruvate kinase family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.974

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006289

Nucleotide-excision repair

5 of 35

2.34

3.36

2.46e-07

GO:0006354

DNA-templated transcription, elongation

4 of 26

2.37

2.56

1.23e-05

GO:0006283

Transcription-coupled nucleotide-excision repair

3 of 7

2.82

2.25

7.60e-05

GO:0006368

Transcription elongation from RNA polymerase II promoter

3 of 24

2.28

1.74

0.00050

GO:0009411

Response to UV

4 of 84

1.86

1.67

0.00034

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000993

RNA polymerase II complex binding

3 of 32

2.16

1.29

0.0036

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008023

Transcription elongation factor complex

4 of 44

2.14

2.31

2.55e-05

GO:0016593

Cdc73/Paf1 complex

2 of 7

2.64

1.49

0.0019

GO:0000109

Nucleotide-excision repair complex

2 of 6

2.71

1.49

0.0019

GO:0031464

Cul4A-RING E3 ubiquitin ligase complex

2 of 10

2.48

1.36

0.0031

GO:0016591

RNA polymerase II, holoenzyme

3 of 69

1.82

1.34

0.0019

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:27507608

(2017) Cockayne syndrome: Clinical features, model systems and pathways.

4 of 8

2.88

2.87

5.56e-06

PMID:30753618

(2019) Structural basis of ubiquitin recognition by the winged-helix domain of Cockayne syndrome group B protein.

3 of 8

2.76

1.52

0.0017

PMID:32649862

(2020) A Genetic Map of the Response to DNA Damage in Human Cells.

4 of 50

2.09

1.44

0.0017

PMID:33007515

(2020) Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair.

3 of 17

2.43

1.18

0.0067

PMID:36077479

(2022) Genome of Laudakia sacra Provides New Insights into High-Altitude Adaptation of Ectotherms.

3 of 34

2.13

0.78

0.0362

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7860

Nucleotide-excision repair factor 1 complex, and Double-strand break repair via classical nonhomologous end joining

3 of 5

2.96

2.39

4.45e-05

CL:9183

Mixed, incl. BAT3 complex binding, and Zinc finger, SIAH-type

2 of 5

2.79

1.1

0.0104

CL:7139

RNA Polymerase II Pre-transcription Events, and Mediator complex

3 of 121

1.58

0.67

0.0448

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

gga03420

Nucleotide excision repair

5 of 35

2.34

4.14

4.50e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

GGA-6781823

Formation of TC-NER Pre-Incision Complex

3 of 38

2.08

1.28

0.0035

GGA-6782210

Gap-filling DNA repair synthesis and ligation in TC-NER

3 of 43

2.03

1.27

0.0035

GGA-6782135

Dual incision in TC-NER

3 of 46

2.0

1.27

0.0035

GGA-353303

Nucleotide Excision Repair

2 of 12

2.41

1.1

0.0094

GGA-73762

RNA Polymerase I Transcription Initiation

2 of 31

1.99

0.74

0.0404

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0008023

Transcription elongation factor complex

3 of 37

2.09

1.53

0.0011

GOCC:0016593

Cdc73/Paf1 complex

2 of 8

2.58

1.37

0.0031

GOCC:0016591

RNA polymerase II, holoenzyme

3 of 63

1.86

1.36

0.0018

GOCC:0000109

Nucleotide-excision repair complex

2 of 10

2.48

1.32

0.0037

GOCC:0031464

Cul4A-RING E3 ubiquitin ligase complex

2 of 11

2.44

1.31

0.0039

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0234

DNA repair

3 of 76

1.78

1.08

0.0068

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