E(spl)/hairy-b protein (Ciona intestinalis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

E(spl)/hairy-b

Uncharacterized protein. (333 aa)

Predicted Functional Partners:

F6YH17_CIOIN

0.782

groucho1

0.663

groucho2

0.663

su(h)

0.632

F7B5L6_CIOIN

0.632

LOC100175446

0.594

F6YWM5_CIOIN

0.561

F6QRK3_CIOIN

0.556

neurogenin

0.542

F6SLD6_CIOIN

0.513

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
E(spl)/hairy-b	F6QRK3_CIOIN	ENSCINP00000010322	ENSCINP00000013234	Uncharacterized protein.	Uncharacterized protein.	0.556
E(spl)/hairy-b	F6SLD6_CIOIN	ENSCINP00000010322	ENSCINP00000027486	Uncharacterized protein.	Deacetylase sirtuin-type domain-containing protein.	0.513
E(spl)/hairy-b	F6YH17_CIOIN	ENSCINP00000010322	ENSCINP00000010771	Uncharacterized protein.	BHLH domain-containing protein.	0.782
E(spl)/hairy-b	F6YWM5_CIOIN	ENSCINP00000010322	ENSCINP00000024568	Uncharacterized protein.	BHLH domain-containing protein.	0.561
E(spl)/hairy-b	F7B5L6_CIOIN	ENSCINP00000010322	ENSCINP00000008655	Uncharacterized protein.	Uncharacterized protein.	0.632
E(spl)/hairy-b	LOC100175446	ENSCINP00000010322	ENSCINP00000034811	Uncharacterized protein.	Uncharacterized protein.	0.594
E(spl)/hairy-b	groucho1	ENSCINP00000010322	ENSCINP00000017742	Uncharacterized protein.	Groucho.	0.663
E(spl)/hairy-b	groucho2	ENSCINP00000010322	ENSCINP00000017756	Uncharacterized protein.	Uncharacterized protein.	0.663
E(spl)/hairy-b	neurogenin	ENSCINP00000010322	ENSCINP00000008328	Uncharacterized protein.	Transcription factor protein isoform X1.	0.542
E(spl)/hairy-b	su(h)	ENSCINP00000010322	ENSCINP00000001527	Uncharacterized protein.	Suppressor of hairless homolog; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes (By similarity). Required for the transcriptional expression of Brachyury, suggesting that it participates in notochord differentiation.	0.632
F6QRK3_CIOIN	E(spl)/hairy-b	ENSCINP00000013234	ENSCINP00000010322	Uncharacterized protein.	Uncharacterized protein.	0.556
F6QRK3_CIOIN	F7B5L6_CIOIN	ENSCINP00000013234	ENSCINP00000008655	Uncharacterized protein.	Uncharacterized protein.	0.676
F6QRK3_CIOIN	su(h)	ENSCINP00000013234	ENSCINP00000001527	Uncharacterized protein.	Suppressor of hairless homolog; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes (By similarity). Required for the transcriptional expression of Brachyury, suggesting that it participates in notochord differentiation.	0.676
F6SLD6_CIOIN	E(spl)/hairy-b	ENSCINP00000027486	ENSCINP00000010322	Deacetylase sirtuin-type domain-containing protein.	Uncharacterized protein.	0.513
F6YH17_CIOIN	E(spl)/hairy-b	ENSCINP00000010771	ENSCINP00000010322	BHLH domain-containing protein.	Uncharacterized protein.	0.782
F6YH17_CIOIN	F6YWM5_CIOIN	ENSCINP00000010771	ENSCINP00000024568	BHLH domain-containing protein.	BHLH domain-containing protein.	0.781
F6YH17_CIOIN	neurogenin	ENSCINP00000010771	ENSCINP00000008328	BHLH domain-containing protein.	Transcription factor protein isoform X1.	0.797
F6YWM5_CIOIN	E(spl)/hairy-b	ENSCINP00000024568	ENSCINP00000010322	BHLH domain-containing protein.	Uncharacterized protein.	0.561
F6YWM5_CIOIN	F6YH17_CIOIN	ENSCINP00000024568	ENSCINP00000010771	BHLH domain-containing protein.	BHLH domain-containing protein.	0.781
F7B5L6_CIOIN	E(spl)/hairy-b	ENSCINP00000008655	ENSCINP00000010322	Uncharacterized protein.	Uncharacterized protein.	0.632