Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
F6Z0U7_CIOINUncharacterized protein. (131 aa)    
Predicted Functional Partners:
LOC101243380
Uncharacterized protein LOC101243380; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.
  
 0.912
LOC100178002
Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.
      
 0.838
F7BF63_CIOIN
Aminotran_5 domain-containing protein.
 
     0.598
H2XNB1_CIOIN
Elp3 domain-containing protein.
  
 
 0.590
F7A1S8_CIOIN
Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...]
  
 
 0.548
F7APB5_CIOIN
Uncharacterized protein.
    
 0.540
F6X3A0_CIOIN
CS domain-containing protein.
    
   0.510
F6YIX1_CIOIN
Uncharacterized protein.
  
 
 0.491
F6SCU4_CIOIN
Aminotran_5 domain-containing protein.
  
 
 0.491
F6UUA2_CIOIN
Aminotran_5 domain-containing protein.
  
 
 0.491
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt
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