Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
F6YHS8_CIOINPCI domain-containing protein. (458 aa)    
Predicted Functional Partners:
LOC100186374
26S proteasome non-ATPase regulatory subunit 11.
   
 0.999
F6XKP0_CIOIN
AAA domain-containing protein; Belongs to the AAA ATPase family.
   
 0.999
F7BHP4_CIOIN
AAA domain-containing protein; Belongs to the AAA ATPase family.
   
 0.999
LOC100182082
AAA domain-containing protein; Belongs to the AAA ATPase family.
   
 0.999
F6UXR3_CIOIN
26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.
   
 0.999
LOC100184190
AAA domain-containing protein; Belongs to the AAA ATPase family.
   
 0.999
F6TTI3_CIOIN
Ubiquitin carboxyl-terminal hydrolase.
   
 0.999
LOC100184510
PCI domain-containing protein.
   
 0.999
LOC100185096
26S proteasome regulatory subunit 7; Belongs to the AAA ATPase family.
   
 0.999
F7BLS5_CIOIN
PCI domain-containing protein.
   
 0.999
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt
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