Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LOC100179869Checkpoint protein; Belongs to the HUS1 family. (286 aa)    
Predicted Functional Partners:
F6XMX2_CIOIN
Uncharacterized protein.
    
 0.999
LOC100175771
Cell cycle checkpoint control protein; Belongs to the rad9 family.
    
 0.999
F6WC79_CIOIN
Uncharacterized protein.
   
 0.992
LOC100181635
AAA domain-containing protein.
   
 0.968
LOC100181422
Replication factor C subunit 2-like.
    
 0.967
LOC100179894
Werner syndrome ATP-dependent helicase homolog isoform X1.
    
 0.945
LOC100184859
Replication factor C subunit 3-like.
    
 0.945
H2XKT2_CIOIN
3'-5' exonuclease domain-containing protein.
    
 0.945
LOC100182514
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
    
 0.937
LOC100179093
AAA domain-containing protein.
    
 0.930
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt
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