Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
F6S5L9_CIOINSH3 domain-containing protein. (774 aa)    
Predicted Functional Partners:
LOC100185663
Vinculin.
    
 0.965
F6WUP4_CIOIN
Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.
   
 0.964
LOC100182146
Uncharacterized protein.
    
 0.923
H2XS74_CIOIN
Uncharacterized protein.
    
 0.892
H2XUL2_CIOIN
Uncharacterized protein.
    
 0.892
MCM7
DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]
    
 0.838
F6YEG0_CIOIN
Peptidase_M3 domain-containing protein.
      
 0.838
F6ZJN0_CIOIN
Uncharacterized protein.
      
 0.833
H2XV03_CIOIN
Uncharacterized protein.
    
 
 0.823
F6V921_CIOIN
Uncharacterized protein.
    
 0.817
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt
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