zf(c3h)-12 protein (Ciona intestinalis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

zf(c3h)-12

Uncharacterized protein. (413 aa)

Predicted Functional Partners:

LOC100181928

0.999

F6SBF1_CIOIN

0.999

LOC100177488

0.998

LOC100183284

0.998

F6W453_CIOIN

0.994

F7A5V7_CIOIN

0.994

LOC100175824

0.994

F6RKQ2_CIOIN

0.991

F6W8G0_CIOIN

0.989

F6ZP18_CIOIN

0.988

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6RKQ2_CIOIN	F6SBF1_CIOIN	ENSCINP00000013154	ENSCINP00000014368	Uncharacterized protein.	Uncharacterized protein.	0.999
F6RKQ2_CIOIN	F6W453_CIOIN	ENSCINP00000013154	ENSCINP00000016360	Uncharacterized protein.	Uncharacterized protein.	0.999
F6RKQ2_CIOIN	F6W8G0_CIOIN	ENSCINP00000013154	ENSCINP00000019657	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.983
F6RKQ2_CIOIN	F6ZP18_CIOIN	ENSCINP00000013154	ENSCINP00000006624	Uncharacterized protein.	Uncharacterized protein.	0.998
F6RKQ2_CIOIN	F7A5V7_CIOIN	ENSCINP00000013154	ENSCINP00000018919	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.999
F6RKQ2_CIOIN	LOC100175824	ENSCINP00000013154	ENSCINP00000019043	Uncharacterized protein.	116 kDa U5 small nuclear ribonucleoprotein component.	0.987
F6RKQ2_CIOIN	LOC100177488	ENSCINP00000013154	ENSCINP00000003205	Uncharacterized protein.	Protein BUD31 homolog.	0.984
F6RKQ2_CIOIN	LOC100181928	ENSCINP00000013154	ENSCINP00000005514	Uncharacterized protein.	Uncharacterized protein.	0.995
F6RKQ2_CIOIN	LOC100183284	ENSCINP00000013154	ENSCINP00000017139	Uncharacterized protein.	SKIP_SNW domain-containing protein.	0.986
F6RKQ2_CIOIN	zf(c3h)-12	ENSCINP00000013154	ENSCINP00000012055	Uncharacterized protein.	Uncharacterized protein.	0.991
F6SBF1_CIOIN	F6RKQ2_CIOIN	ENSCINP00000014368	ENSCINP00000013154	Uncharacterized protein.	Uncharacterized protein.	0.999
F6SBF1_CIOIN	F6W453_CIOIN	ENSCINP00000014368	ENSCINP00000016360	Uncharacterized protein.	Uncharacterized protein.	0.996
F6SBF1_CIOIN	F6W8G0_CIOIN	ENSCINP00000014368	ENSCINP00000019657	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.991
F6SBF1_CIOIN	F6ZP18_CIOIN	ENSCINP00000014368	ENSCINP00000006624	Uncharacterized protein.	Uncharacterized protein.	0.998
F6SBF1_CIOIN	F7A5V7_CIOIN	ENSCINP00000014368	ENSCINP00000018919	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.994
F6SBF1_CIOIN	LOC100175824	ENSCINP00000014368	ENSCINP00000019043	Uncharacterized protein.	116 kDa U5 small nuclear ribonucleoprotein component.	0.996
F6SBF1_CIOIN	LOC100177488	ENSCINP00000014368	ENSCINP00000003205	Uncharacterized protein.	Protein BUD31 homolog.	0.998
F6SBF1_CIOIN	LOC100181928	ENSCINP00000014368	ENSCINP00000005514	Uncharacterized protein.	Uncharacterized protein.	0.999
F6SBF1_CIOIN	LOC100183284	ENSCINP00000014368	ENSCINP00000017139	Uncharacterized protein.	SKIP_SNW domain-containing protein.	0.998
F6SBF1_CIOIN	zf(c3h)-12	ENSCINP00000014368	ENSCINP00000012055	Uncharacterized protein.	Uncharacterized protein.	0.999

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.845

expected number of edges:

10

PPI enrichment p-value:

0.000782

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007264

Small GTPase mediated signal transduction

6 of 207

1.64

1.94

2.04e-05

GO:0007265

Ras protein signal transduction

5 of 152

1.69

1.74

0.00012

GO:0035556

Intracellular signal transduction

9 of 1154

1.07

1.13

2.04e-05

GO:0071803

Positive regulation of podosome assembly

2 of 9

2.52

0.86

0.0270

GO:1902117

Positive regulation of organelle assembly

3 of 72

1.8

0.85

0.0226

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070290

N-acylphosphatidylethanolamine-specific phospholipase D activity

2 of 3

3.0

1.07

0.0119

GO:0004630

Phospholipase D activity

2 of 3

3.0

1.07

0.0119

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000145

Exocyst

2 of 16

2.27

0.72

0.0472

GO:0071944

Cell periphery

10 of 4170

0.56

0.39

0.0137

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:12878

Mixed, incl. Rho (Ras homology) subfamily of Ras-like small GTPases, and RHOU GTPase cycle

4 of 38

2.2

2.23

4.34e-05

CL:12871

Mixed, incl. Small GTPase mediated signal transduction, and RHO GTPases Activate WASPs and WAVEs

5 of 193

1.59

1.67

0.00010

CL:11806

Phospholipase D. Active site motifs.

2 of 5

2.78

1.33

0.0039

CL:20320

Exocyst

2 of 6

2.7

1.28

0.0046

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04014

Ras signaling pathway

10 of 225

1.83

4.82

1.04e-15

map05212

Pancreatic cancer

6 of 75

2.08

4.05

9.00e-10

map04072

Phospholipase D signaling pathway

5 of 154

1.69

2.25

2.96e-06

map05210

Colorectal cancer

4 of 89

1.83

2.13

2.09e-05

map05231

Choline metabolism in cancer

4 of 99

1.78

2.05

2.63e-05

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0004012

ROS cell

2 of 2

3.18

1.28

0.0049

BTO:0003432

EL-4 cell

2 of 2

3.18

1.28

0.0049

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0098981

Cholinergic synapse

2 of 5

2.78

1.0

0.0152

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00229

Guanine nucleotide exchange factor for Ras-like GTPases

3 of 18

2.4

1.95

0.00022

SM00147

Guanine nucleotide exchange factor for Ras-like small GTPases

3 of 25

2.26

1.87

0.00027

SM00314

Ras association (RalGDS/AF-6) domain

3 of 28

2.21

1.86

0.00027

SM00155

Phospholipase D. Active site motifs.

2 of 5

2.78

1.54

0.0016

SM00312

PhoX homologous domain, present in p47phox and p40phox.

2 of 34

1.95

0.75

0.0386

(more ...)

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