Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC100180811Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. (258 aa)    
Predicted Functional Partners:
LOC100182516
RING-box protein 1.
    
 0.984
F6PW28_CIOIN
CULLIN_2 domain-containing protein; Belongs to the cullin family.
   
 0.982
LOC100183130
CULLIN_2 domain-containing protein; Belongs to the cullin family.
   
 0.967
F6R472_CIOIN
CULLIN_2 domain-containing protein; Belongs to the cullin family.
   
 0.962
LOC100176246
Ubiquitin-like domain-containing protein.
    
 0.955
LOC100175879
CULLIN_2 domain-containing protein; Belongs to the cullin family.
    
 0.931
F6PKZ6_CIOIN
CULLIN_2 domain-containing protein; Belongs to the cullin family.
   
 0.931
LOC100181334
NEDD8-conjugating enzyme UBE2F-like isoform X1; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.930
LOC100177347
NEDD8-conjugating enzyme Ubc12-like; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.930
H2XUY6_CIOIN
Cullin_Nedd8 domain-containing protein; Belongs to the cullin family.
   
 0.893
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt
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