F6YV51_CIOIN protein (Ciona intestinalis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

F6YV51_CIOIN

U-box domain-containing protein. (925 aa)

Predicted Functional Partners:

F7B3P4_CIOIN

0.871

F7AP04_CIOIN

0.862

F7A5L4_CIOIN

0.847

LOC100178793

0.839

LOC100175472

0.812

F6WRI9_CIOIN

0.791

H2XLP4_CIOIN

0.791

H2XPT0_CIOIN

0.791

F6SW03_CIOIN

0.769

LOC100187157

0.731

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6SW03_CIOIN	F6YV51_CIOIN	ENSCINP00000002958	ENSCINP00000014127	Uncharacterized protein.	U-box domain-containing protein.	0.769
F6SW03_CIOIN	F7A5L4_CIOIN	ENSCINP00000002958	ENSCINP00000027298	Uncharacterized protein.	MPN domain-containing protein.	0.805
F6SW03_CIOIN	F7AP04_CIOIN	ENSCINP00000002958	ENSCINP00000015288	Uncharacterized protein.	Uncharacterized protein.	0.894
F6SW03_CIOIN	LOC100178793	ENSCINP00000002958	ENSCINP00000034086	Uncharacterized protein.	OTU domain-containing protein.	0.962
F6SW03_CIOIN	LOC100187157	ENSCINP00000002958	ENSCINP00000014598	Uncharacterized protein.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.927
F6WRI9_CIOIN	F6YV51_CIOIN	ENSCINP00000016316	ENSCINP00000014127	HECT domain-containing protein.	U-box domain-containing protein.	0.791
F6WRI9_CIOIN	F7AP04_CIOIN	ENSCINP00000016316	ENSCINP00000015288	HECT domain-containing protein.	Uncharacterized protein.	0.497
F6WRI9_CIOIN	F7B3P4_CIOIN	ENSCINP00000016316	ENSCINP00000017031	HECT domain-containing protein.	Uncharacterized protein.	0.678
F6WRI9_CIOIN	H2XLP4_CIOIN	ENSCINP00000016316	ENSCINP00000030576	HECT domain-containing protein.	Uncharacterized protein.	0.925
F6WRI9_CIOIN	H2XPT0_CIOIN	ENSCINP00000016316	ENSCINP00000031664	HECT domain-containing protein.	Uncharacterized protein.	0.410
F6WRI9_CIOIN	LOC100175472	ENSCINP00000016316	ENSCINP00000017880	HECT domain-containing protein.	Ubiquilin-1.	0.688
F6YV51_CIOIN	F6SW03_CIOIN	ENSCINP00000014127	ENSCINP00000002958	U-box domain-containing protein.	Uncharacterized protein.	0.769
F6YV51_CIOIN	F6WRI9_CIOIN	ENSCINP00000014127	ENSCINP00000016316	U-box domain-containing protein.	HECT domain-containing protein.	0.791
F6YV51_CIOIN	F7A5L4_CIOIN	ENSCINP00000014127	ENSCINP00000027298	U-box domain-containing protein.	MPN domain-containing protein.	0.847
F6YV51_CIOIN	F7AP04_CIOIN	ENSCINP00000014127	ENSCINP00000015288	U-box domain-containing protein.	Uncharacterized protein.	0.862
F6YV51_CIOIN	F7B3P4_CIOIN	ENSCINP00000014127	ENSCINP00000017031	U-box domain-containing protein.	Uncharacterized protein.	0.871
F6YV51_CIOIN	H2XLP4_CIOIN	ENSCINP00000014127	ENSCINP00000030576	U-box domain-containing protein.	Uncharacterized protein.	0.791
F6YV51_CIOIN	H2XPT0_CIOIN	ENSCINP00000014127	ENSCINP00000031664	U-box domain-containing protein.	Uncharacterized protein.	0.791
F6YV51_CIOIN	LOC100175472	ENSCINP00000014127	ENSCINP00000017880	U-box domain-containing protein.	Ubiquilin-1.	0.812
F6YV51_CIOIN	LOC100178793	ENSCINP00000014127	ENSCINP00000034086	U-box domain-containing protein.	OTU domain-containing protein.	0.839

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.896

expected number of edges:

14

PPI enrichment p-value:

0.0178

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0060271

Cilium assembly

10 of 282

1.91

5.12

3.08e-15

GO:1905515

Non-motile cilium assembly

5 of 44

2.42

4.06

1.02e-08

GO:0007224

Smoothened signaling pathway

5 of 60

2.28

3.67

3.90e-08

GO:1904491

Protein localization to ciliary transition zone

3 of 6

3.06

3.0

3.47e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0036038

MKS complex

10 of 11

3.32

14.87

1.59e-28

GO:0060170

Ciliary membrane

4 of 50

2.27

2.98

1.26e-06

GO:0036064

Ciliary basal body

3 of 134

1.71

1.19

0.0035

GO:0005813

Centrosome

4 of 433

1.33

1.0

0.0035

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:23870701

(2013) Joubert syndrome: congenital cerebellar ataxia with the molar tooth.

6 of 25

2.74

5.34

7.18e-11

PMID:26673778

(2016) Large-scale targeted sequencing comparison highlights extreme genetic heterogeneity in nephronophthisis-related ciliopathies.

6 of 28

2.69

5.31

7.18e-11

PMID:25729630

(2014) Unraveling the genetics of Joubert and Meckel-Gruber syndromes.

6 of 30

2.66

5.28

7.18e-11

PMID:28401750

(2017) The Ciliary Transition Zone: Finding the Pieces and Assembling the Gate.

6 of 35

2.6

5.14

1.09e-10

PMID:23352055

(2012) The transition zone: an essential functional compartment of cilia.

6 of 37

2.57

5.1

1.19e-10

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15866

Mixed, incl. Intraciliary transport particle, and Ciliary transition zone

11 of 76

2.52

10.72

2.14e-24

CL:15875

Mixed, incl. MKS complex, and Pronephros formation

8 of 20

2.97

9.88

1.29e-19

CL:15878

MKS complex, and Protein localization to ciliary transition zone

6 of 14

3.0

7.26

2.60e-14

CL:15880

MKS complex, and Predicted membrane protein

5 of 8

3.16

6.24

3.33e-12

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

DRE-5620912

Anchoring of the basal body to the plasma membrane

4 of 83

2.05

2.07

6.69e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0036038

MKS complex

11 of 14

3.26

16.39

9.85e-32

GOCC:0060170

Ciliary membrane

3 of 42

2.22

1.93

0.00019

GOCC:0036064

Ciliary basal body

2 of 53

1.94

0.74

0.0394

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0970

Cilium biogenesis/degradation

6 of 55

2.4

5.18

2.81e-11

KW-0969

Cilium

4 of 64

2.16

2.81

2.10e-06

KW-0966

Cell projection

5 of 160

1.86

2.63

1.01e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07162

Ciliary basal body-associated, B9 protein

3 of 3

3.36

3.07

2.90e-06

PF14995

Transmembrane protein

2 of 2

3.36

1.62

0.0012

PF09799

Predicted membrane protein

2 of 3

3.19

1.58

0.0014

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR010796

B9-type C2 domain

3 of 3

3.36

2.87

6.69e-06

IPR029248

Transmembrane protein 107

2 of 2

3.36

1.42

0.0028

IPR019184

Uncharacterised protein family, transmembrane-17

2 of 3

3.19

1.39

0.0031

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