Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC1001752953-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (501 aa)    
Predicted Functional Partners:
H2Y2K4_CIOIN
3-hydroxy-3-methylglutaryl coenzyme A reductase.
  
 
 0.999
LOC100177845
acetyl-CoA acetyltransferase, mitochondrial-like; Belongs to the thiolase-like superfamily. Thiolase family.
  
 0.998
F6VR09_CIOIN
Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.
  
 0.996
LOC101242316
3-ketoacyl-CoA thiolase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family.
  
 0.991
H2XSN3_CIOIN
Pyruvate carboxyltransferase domain-containing protein.
     
 0.987
F6QHP8_CIOIN
Uncharacterized protein; Belongs to the FPP/GGPP synthase family.
  
 
 0.980
F6SSS9_CIOIN
Nudix hydrolase domain-containing protein.
  
  
 0.955
LOC100180566
Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
    
 0.951
F6Z0U1_CIOIN
Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.
 
 
 0.948
LOC100185648
Uncharacterized protein.
  
 
 0.942
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt
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