LOC100184902 protein (Ciona intestinalis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LOC100184902

Geminin. (257 aa)

Predicted Functional Partners:

LOC100184078

0.999

LOC100182084

0.827

F6RKM9_CIOIN

0.827

LOC100183401

0.777

F6WMK2_CIOIN

0.754

H2XNL8_CIOIN

0.729

LOC108950147

0.727

F7BA18_CIOIN

0.726

LOC100176589

0.720

F6QND3_CIOIN

0.670

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6QND3_CIOIN	F6RKM9_CIOIN	ENSCINP00000009731	ENSCINP00000013159	Mcm10 domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.993
F6QND3_CIOIN	F6WMK2_CIOIN	ENSCINP00000009731	ENSCINP00000010257	Mcm10 domain-containing protein.	MCM domain-containing protein; Belongs to the MCM family.	0.965
F6QND3_CIOIN	F7BA18_CIOIN	ENSCINP00000009731	ENSCINP00000006895	Mcm10 domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.982
F6QND3_CIOIN	H2XNL8_CIOIN	ENSCINP00000009731	ENSCINP00000031251	Mcm10 domain-containing protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.918
F6QND3_CIOIN	LOC100176589	ENSCINP00000009731	ENSCINP00000014916	Mcm10 domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.991
F6QND3_CIOIN	LOC100182084	ENSCINP00000009731	ENSCINP00000003393	Mcm10 domain-containing protein.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.991
F6QND3_CIOIN	LOC100183401	ENSCINP00000009731	ENSCINP00000022958	Mcm10 domain-containing protein.	Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family.	0.920
F6QND3_CIOIN	LOC100184078	ENSCINP00000009731	ENSCINP00000033367	Mcm10 domain-containing protein.	CDT1 domain-containing protein.	0.989
F6QND3_CIOIN	LOC100184902	ENSCINP00000009731	ENSCINP00000015197	Mcm10 domain-containing protein.	Geminin.	0.670
F6QND3_CIOIN	LOC108950147	ENSCINP00000009731	ENSCINP00000003001	Mcm10 domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.982
F6RKM9_CIOIN	F6QND3_CIOIN	ENSCINP00000013159	ENSCINP00000009731	DNA helicase; Belongs to the MCM family.	Mcm10 domain-containing protein.	0.993
F6RKM9_CIOIN	F6WMK2_CIOIN	ENSCINP00000013159	ENSCINP00000010257	DNA helicase; Belongs to the MCM family.	MCM domain-containing protein; Belongs to the MCM family.	0.859
F6RKM9_CIOIN	F7BA18_CIOIN	ENSCINP00000013159	ENSCINP00000006895	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
F6RKM9_CIOIN	H2XNL8_CIOIN	ENSCINP00000013159	ENSCINP00000031251	DNA helicase; Belongs to the MCM family.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.988
F6RKM9_CIOIN	LOC100176589	ENSCINP00000013159	ENSCINP00000014916	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
F6RKM9_CIOIN	LOC100182084	ENSCINP00000013159	ENSCINP00000003393	DNA helicase; Belongs to the MCM family.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.999
F6RKM9_CIOIN	LOC100183401	ENSCINP00000013159	ENSCINP00000022958	DNA helicase; Belongs to the MCM family.	Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family.	0.978
F6RKM9_CIOIN	LOC100184078	ENSCINP00000013159	ENSCINP00000033367	DNA helicase; Belongs to the MCM family.	CDT1 domain-containing protein.	0.998
F6RKM9_CIOIN	LOC100184902	ENSCINP00000013159	ENSCINP00000015197	DNA helicase; Belongs to the MCM family.	Geminin.	0.827
F6RKM9_CIOIN	LOC108950147	ENSCINP00000013159	ENSCINP00000003001	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999

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Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.968

expected number of edges:

10

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045039

Protein insertion into mitochondrial inner membrane

3 of 7

3.0

2.53

2.54e-05

GO:0046834

Lipid phosphorylation

2 of 2

3.37

1.79

0.00060

GO:0046512

Sphingosine biosynthetic process

2 of 5

2.97

1.59

0.0013

GO:0006121

Mitochondrial electron transport, succinate to ubiquinone

2 of 6

2.89

1.59

0.0013

GO:0006099

Tricarboxylic acid cycle

2 of 29

2.2

1.05

0.0111

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140318

Protein transporter activity

3 of 25

2.44

1.87

0.00032

GO:0004402

Histone acetyltransferase activity

2 of 23

2.3

0.85

0.0274

GO:0140110

Transcription regulator activity

4 of 412

1.35

0.78

0.0171

GO:0046872

Metal ion binding

6 of 2233

0.79

0.46

0.0331

GO:0005488

Binding

10 of 7866

0.47

0.32

0.0274

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042721

TIM22 mitochondrial import inner membrane insertion complex

3 of 4

3.24

3.32

9.53e-07

GO:0098800

Inner mitochondrial membrane protein complex

5 of 120

1.99

2.79

9.53e-07

GO:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 3

3.19

2.13

0.00014

GO:0005749

Mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)

2 of 5

2.97

1.98

0.00026

GO:0032991

Protein-containing complex

6 of 2897

0.68

0.45

0.0164

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:24142

Tim10-like, and TIM22 mitochondrial import inner membrane insertion complex

3 of 7

3.0

2.59

1.96e-05

CL:19911

Fumarate reductase complex

2 of 5

2.97

1.48

0.0021

CL:1544

Mixed, incl. Lectin, and Met-10+ like-protein

2 of 11

2.63

1.31

0.0040

CL:21436

Sphingolipid metabolism

2 of 18

2.41

1.12

0.0088

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00020

Citrate cycle (TCA cycle)

2 of 49

1.98

0.79

0.0330

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1268020

Mitochondrial protein import

3 of 72

1.99

1.25

0.0037

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 4

3.06

1.6

0.0013

GOCC:0045281

Succinate dehydrogenase complex

2 of 7

2.82

1.52

0.0017

GOCC:0098798

Mitochondrial protein complex

4 of 184

1.7

1.42

0.00090

GOCC:0005740

Mitochondrial envelope

4 of 367

1.4

1.12

0.0019

GOCC:0098800

Inner mitochondrial membrane protein complex

2 of 75

1.79

0.82

0.0255

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

2 of 13

2.55

1.41

0.0026

KW-0496

Mitochondrion

3 of 102

1.83

1.28

0.0026

KW-1015

Disulfide bond

2 of 92

1.7

0.7

0.0428

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02953

Tim10/DDP family zinc finger

2 of 4

3.06

1.41

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR034804

Fumarate reductase/succinate dehydrogenase, transmembrane subunit

2 of 3

3.19

1.39

0.0032

IPR001206

Diacylglycerol kinase, catalytic domain

2 of 2

3.37

1.39

0.0032

IPR035427

Tim10-like domain superfamily

2 of 4

3.06

1.38

0.0032

IPR017438

Inorganic polyphosphate/ATP-NAD kinase, N-terminal

2 of 5

2.97

1.38

0.0032

IPR016064

NAD kinase/diacylglycerol kinase-like domain superfamily

2 of 5

2.97

1.38

0.0032

(more ...)

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