Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
F6T8A4_CIOINNon-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (297 aa)    
Predicted Functional Partners:
F7AE79_CIOIN
SP-RING-type domain-containing protein.
    
 0.999
F6YHQ3_CIOIN
zf-RING-like domain-containing protein.
   
 0.999
LOC100181789
AAA_23 domain-containing protein.
   
 0.999
H2XL64_CIOIN
SMC_N domain-containing protein.
   
 0.999
LOC100181542
Non-structural maintenance of chromosomes element 3 homolog isoform X1.
   
 0.998
F6WUJ1_CIOIN
Structural maintenance of chromosomes protein.
   
 0.837
LOC100186777
ANK_REP_REGION domain-containing protein.
    
 
 0.696
F7ADN1_CIOIN
Structural maintenance of chromosomes protein.
   
 0.693
LOC100180856
Rad21_Rec8 domain-containing protein.
   
 
 0.666
H2XMB6_CIOIN
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
     
 0.659
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.