Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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LOC100176021Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (407 aa)    
Predicted Functional Partners:
LOC100186367
Gamma-aminobutyric acid receptor-associated protein.
  
 0.999
LOC100178444
Microtubule-associated proteins 1A/1B light chain 3B-like.
   
 0.998
F7A9X0_CIOIN
Protein kinase domain-containing protein.
   
 
 0.981
F6TZ29_CIOIN
Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.
   
 
 0.903
F6SNM2_CIOIN
Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.
   
  
 0.856
LOC101243041
Autophagy_act_C domain-containing protein.
   
 
 0.854
LOC100186746
Autophagy-related protein 3.
   
 
 0.854
LOC101242365
Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.
    
 
 0.848
atg5
Autophagy protein 5; Involved in autophagic vesicle formation.
   
 
 0.831
F7ADE5_CIOIN
APG6 domain-containing protein.
    
 
 0.817
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt
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