STRINGSTRING
top3b protein (Ciona intestinalis) - STRING interaction network
"top3b" - DNA topoisomerase in Ciona intestinalis
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
top3bDNA topoisomerase ; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand (820 aa)    
Predicted Functional Partners:
ENSCING00000002265
Uncharacterized protein (486 aa)
     
  0.973
ENSCING00000021036
Uncharacterized protein (549 aa)
   
  0.960
Cin.29239
Uncharacterized protein (622 aa)
   
  0.960
ENSCING00000022501
Uncharacterized protein (229 aa)
     
  0.953
ENSCING00000023482
Uncharacterized protein (607 aa)
   
  0.937
ENSCING00000002232
Uncharacterized protein (1194 aa)
   
  0.920
ENSCING00000001864
Uncharacterized protein (431 aa)
     
  0.916
ENSCING00000010863
Uncharacterized protein (274 aa)
     
  0.904
ENSCING00000021332
Uncharacterized protein (118 aa)
       
    0.893
ENSCING00000021898
Uncharacterized protein (133 aa)
     
  0.891
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: C. intestinalis, Ciona intestinalis
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