F6Z781_CIOIN protein (Ciona intestinalis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

F6Z781_CIOIN

Calreticulin. (425 aa)

Predicted Functional Partners:

F7B397_CIOIN

0.958

F6XY03_CIOIN

0.948

H2XRE2_CIOIN

0.948

H2XQ03_CIOIN

0.894

F6WYW5_CIOIN

0.867

LOC100184179

0.867

LOC100186609

0.862

LOC101242470

0.862

H2Y1S7_CIOIN

0.840

F6TUR1_CIOIN

0.839

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6TUR1_CIOIN	F6WYW5_CIOIN	ENSCINP00000008588	ENSCINP00000005773	Thioredoxin domain-containing protein; Belongs to the protein disulfide isomerase family.	Protein disulfide-isomerase.	0.581
F6TUR1_CIOIN	F6XY03_CIOIN	ENSCINP00000008588	ENSCINP00000015093	Thioredoxin domain-containing protein; Belongs to the protein disulfide isomerase family.	HATPase_c domain-containing protein.	0.773
F6TUR1_CIOIN	F6Z781_CIOIN	ENSCINP00000008588	ENSCINP00000016510	Thioredoxin domain-containing protein; Belongs to the protein disulfide isomerase family.	Calreticulin.	0.839
F6TUR1_CIOIN	F7B397_CIOIN	ENSCINP00000008588	ENSCINP00000005300	Thioredoxin domain-containing protein; Belongs to the protein disulfide isomerase family.	Uncharacterized protein.	0.514
F6TUR1_CIOIN	H2XQ03_CIOIN	ENSCINP00000008588	ENSCINP00000031737	Thioredoxin domain-containing protein; Belongs to the protein disulfide isomerase family.	Uncharacterized protein.	0.592
F6TUR1_CIOIN	H2XRE2_CIOIN	ENSCINP00000008588	ENSCINP00000032226	Thioredoxin domain-containing protein; Belongs to the protein disulfide isomerase family.	HATPase_c domain-containing protein.	0.773
F6TUR1_CIOIN	LOC100184179	ENSCINP00000008588	ENSCINP00000013204	Thioredoxin domain-containing protein; Belongs to the protein disulfide isomerase family.	Protein disulfide-isomerase.	0.553
F6TUR1_CIOIN	LOC100186609	ENSCINP00000008588	ENSCINP00000019205	Thioredoxin domain-containing protein; Belongs to the protein disulfide isomerase family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.704
F6TUR1_CIOIN	LOC101242470	ENSCINP00000008588	ENSCINP00000019494	Thioredoxin domain-containing protein; Belongs to the protein disulfide isomerase family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.704
F6WYW5_CIOIN	F6TUR1_CIOIN	ENSCINP00000005773	ENSCINP00000008588	Protein disulfide-isomerase.	Thioredoxin domain-containing protein; Belongs to the protein disulfide isomerase family.	0.581
F6WYW5_CIOIN	F6XY03_CIOIN	ENSCINP00000005773	ENSCINP00000015093	Protein disulfide-isomerase.	HATPase_c domain-containing protein.	0.585
F6WYW5_CIOIN	F6Z781_CIOIN	ENSCINP00000005773	ENSCINP00000016510	Protein disulfide-isomerase.	Calreticulin.	0.867
F6WYW5_CIOIN	F7B397_CIOIN	ENSCINP00000005773	ENSCINP00000005300	Protein disulfide-isomerase.	Uncharacterized protein.	0.715
F6WYW5_CIOIN	H2XQ03_CIOIN	ENSCINP00000005773	ENSCINP00000031737	Protein disulfide-isomerase.	Uncharacterized protein.	0.615
F6WYW5_CIOIN	H2XRE2_CIOIN	ENSCINP00000005773	ENSCINP00000032226	Protein disulfide-isomerase.	HATPase_c domain-containing protein.	0.585
F6WYW5_CIOIN	H2Y1S7_CIOIN	ENSCINP00000005773	ENSCINP00000035861	Protein disulfide-isomerase.	Thioredoxin domain-containing protein; Belongs to the protein disulfide isomerase family.	0.576
F6WYW5_CIOIN	LOC100186609	ENSCINP00000005773	ENSCINP00000019205	Protein disulfide-isomerase.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.810
F6WYW5_CIOIN	LOC101242470	ENSCINP00000005773	ENSCINP00000019494	Protein disulfide-isomerase.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.810
F6XY03_CIOIN	F6TUR1_CIOIN	ENSCINP00000015093	ENSCINP00000008588	HATPase_c domain-containing protein.	Thioredoxin domain-containing protein; Belongs to the protein disulfide isomerase family.	0.773
F6XY03_CIOIN	F6WYW5_CIOIN	ENSCINP00000015093	ENSCINP00000005773	HATPase_c domain-containing protein.	Protein disulfide-isomerase.	0.585

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

16

average node degree:

2.91

avg. local clustering coefficient:

0.861

expected number of edges:

12

PPI enrichment p-value:

0.164

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070286

Axonemal dynein complex assembly

6 of 32

2.55

5.21

6.00e-11

GO:0003341

Cilium movement

7 of 143

1.97

3.85

7.51e-10

GO:0007018

Microtubule-based movement

9 of 337

1.71

3.45

4.91e-11

GO:0044782

Cilium organization

8 of 320

1.68

3.08

1.17e-09

GO:0007017

Microtubule-based process

10 of 725

1.42

2.48

1.06e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045503

Dynein light chain binding

4 of 9

2.93

3.83

8.86e-08

GO:0045504

Dynein heavy chain binding

4 of 13

2.77

3.67

1.47e-07

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005858

Axonemal dynein complex

4 of 15

2.7

3.77

8.49e-08

GO:0030286

Dynein complex

5 of 57

2.22

3.46

8.49e-08

GO:0005875

Microtubule associated complex

6 of 144

1.9

3.05

8.49e-08

GO:0032838

Plasma membrane bounded cell projection cytoplasm

6 of 201

1.75

2.73

1.49e-07

GO:0005930

Axoneme

5 of 140

1.83

2.54

1.47e-06

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33101214

(2020) The Role of Genetics and Oxidative Stress in the Etiology of Male Infertility-A Unifying Hypothesis?

8 of 70

2.34

5.89

2.82e-13

PMID:34768622

(2021) A Study on the Genetics of Primary Ciliary Dyskinesia.

4 of 16

2.68

2.79

6.67e-06

PMID:36714566

(2022) Deleterious variants in TAF7L cause human oligoasthenoteratozoospermia and its impairing histone to protamine exchange inducing reduced in vitro fertilization.

3 of 27

2.32

1.09

0.0097

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17689

Mixed, incl. Dynein complex, and Dynactin complex

8 of 118

2.11

5.13

1.04e-12

CL:17827

Mixed, incl. Axonemal dynein complex assembly, and Dynein heavy chain 3, AAA+ lid domain

6 of 42

2.43

4.96

1.12e-10

CL:17830

Axonemal dynein complex assembly, and Dynein heavy chain, tail

4 of 20

2.58

3.33

5.05e-07

CL:17831

Axonemal dynein complex assembly, and Radial spokehead-like protein

3 of 13

2.64

2.34

4.65e-05

CL:17833

Mixed, incl. Outer dynein arm, and Sperm tail

2 of 7

2.73

1.22

0.0060

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001363

Testis

7 of 793

1.22

1.33

3.48e-05

BTO:0000082

Male reproductive system

8 of 1145

1.12

1.2

2.45e-05

BTO:0000522

Gland

8 of 4071

0.57

0.35

0.0402

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005858

Axonemal dynein complex

5 of 19

2.7

4.73

1.06e-09

GOCC:0005930

Axoneme

6 of 101

2.05

3.7

6.37e-09

GOCC:0005875

Microtubule associated complex

6 of 112

2.01

3.62

6.37e-09

GOCC:0005929

Cilium

7 of 422

1.5

2.26

1.01e-07

GOCC:0036156

Inner dynein arm

2 of 6

2.8

1.65

0.00098

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00320

WD40 repeats

4 of 271

1.45

0.95

0.0073

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