Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Ci-htf-1DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1297 aa)    
Predicted Functional Partners:
F6RCY1_CIOIN
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
   
 
 0.980
H2XM56_CIOIN
CENP-F_N domain-containing protein.
   
  
 0.959
LOC100180482
Structural maintenance of chromosomes protein.
   
 
 0.953
H2XKH3_CIOIN
Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.
   
  
 0.951
F7A0P0_CIOIN
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
   
 
 0.922
H2XL64_CIOIN
SMC_N domain-containing protein.
   
 
 0.918
LOC100178367
Small ubiquitin-related modifier.
    
 0.915
F6QSH0_CIOIN
Uncharacterized protein.
   
 
 0.907
F6PKV2_CIOIN
UBIQUITIN_CONJUGAT_2 domain-containing protein.
   
 0.898
F6X972_CIOIN
Uncharacterized protein.
   
  
 0.895
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt
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