Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Lefty/antivinTGF_BETA_2 domain-containing protein. (385 aa)    
Predicted Functional Partners:
nodal
Transforming growth factor beta superfamily signaling ligand isoform X1.
   
 
 0.964
Tgfbeta2
TGF_BETA_2 domain-containing protein.
     
0.947
tgfbr-iia
Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    
 0.693
pitx
Paired superclass homeobox transcription factor isoform X1.
   
  
 0.579
tgfbr-ic
Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.
    
 0.563
F6Z7A4_CIOIN
DUF4472 domain-containing protein.
      
 0.543
F6W446_CIOIN
E3 ubiquitin-protein ligase.
    
 0.539
tgfbr-ia
Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.
    
 0.458
tgfbr-ib
Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    
 0.458
Tgfbr-iib
Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    
 0.457
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.