Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC100182716Flap endonuclease GEN homolog 1. (709 aa)    
Predicted Functional Partners:
LOC100179894
Werner syndrome ATP-dependent helicase homolog isoform X1.
  
 0.845
H2XKT2_CIOIN
3'-5' exonuclease domain-containing protein.
  
 0.834
F6USX3_CIOIN
Uncharacterized protein.
   
 0.824
F6VD75_CIOIN
Uncharacterized protein.
   
 0.790
F6SK60_CIOIN
Uncharacterized protein.
  
 0.777
F6W2K0_CIOIN
DUF1767 domain-containing protein.
   
 
 0.768
H2Y1I3_CIOIN
Uncharacterized protein.
   
 
 0.709
F6WGY1_CIOIN
Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family.
     
 0.705
LOC100184693
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
  
 0.702
H2XVM4_CIOIN
Rho-GAP domain-containing protein.
      
 0.694
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt
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