F6QF37_CIOIN protein (Ciona intestinalis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

F6QF37_CIOIN

Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (440 aa)

Predicted Functional Partners:

F7BL51_CIOIN

0.999

F7A2X8_CIOIN

0.998

LOC100178564

0.996

LOC100182436

0.982

F6USH9_CIOIN

0.978

F6PG92_CIOIN

0.970

LOC100180887

0.969

F6PHH7_CIOIN

0.954

LOC100184965

0.950

F6YQS6_CIOIN

0.945

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6PG92_CIOIN	F6PHH7_CIOIN	ENSCINP00000013422	ENSCINP00000018277	Uncharacterized protein.	ATP-grasp domain-containing protein.	0.998
F6PG92_CIOIN	F6QF37_CIOIN	ENSCINP00000013422	ENSCINP00000018101	Uncharacterized protein.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	0.970
F6PG92_CIOIN	F7A2X8_CIOIN	ENSCINP00000013422	ENSCINP00000015809	Uncharacterized protein.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.689
F6PG92_CIOIN	F7BL51_CIOIN	ENSCINP00000013422	ENSCINP00000000763	Uncharacterized protein.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.530
F6PG92_CIOIN	LOC100184965	ENSCINP00000013422	ENSCINP00000017065	Uncharacterized protein.	Aspartate aminotransferase.	0.935
F6PHH7_CIOIN	F6PG92_CIOIN	ENSCINP00000018277	ENSCINP00000013422	ATP-grasp domain-containing protein.	Uncharacterized protein.	0.998
F6PHH7_CIOIN	F6QF37_CIOIN	ENSCINP00000018277	ENSCINP00000018101	ATP-grasp domain-containing protein.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	0.954
F6PHH7_CIOIN	F7A2X8_CIOIN	ENSCINP00000018277	ENSCINP00000015809	ATP-grasp domain-containing protein.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.854
F6PHH7_CIOIN	LOC100184965	ENSCINP00000018277	ENSCINP00000017065	ATP-grasp domain-containing protein.	Aspartate aminotransferase.	0.911
F6QF37_CIOIN	F6PG92_CIOIN	ENSCINP00000018101	ENSCINP00000013422	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Uncharacterized protein.	0.970
F6QF37_CIOIN	F6PHH7_CIOIN	ENSCINP00000018101	ENSCINP00000018277	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	ATP-grasp domain-containing protein.	0.954
F6QF37_CIOIN	F6USH9_CIOIN	ENSCINP00000018101	ENSCINP00000023503	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Inosine-5'-monophosphate dehydrogenase; Belongs to the IMPDH/GMPR family.	0.978
F6QF37_CIOIN	F6YQS6_CIOIN	ENSCINP00000018101	ENSCINP00000011173	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.945
F6QF37_CIOIN	F7A2X8_CIOIN	ENSCINP00000018101	ENSCINP00000015809	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.998
F6QF37_CIOIN	F7BL51_CIOIN	ENSCINP00000018101	ENSCINP00000000763	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.999
F6QF37_CIOIN	LOC100178564	ENSCINP00000018101	ENSCINP00000008382	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	MGS domain-containing protein.	0.996
F6QF37_CIOIN	LOC100180887	ENSCINP00000018101	ENSCINP00000025829	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.969
F6QF37_CIOIN	LOC100182436	ENSCINP00000018101	ENSCINP00000013612	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	0.982
F6QF37_CIOIN	LOC100184965	ENSCINP00000018101	ENSCINP00000017065	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Aspartate aminotransferase.	0.950
F6USH9_CIOIN	F6QF37_CIOIN	ENSCINP00000023503	ENSCINP00000018101	Inosine-5'-monophosphate dehydrogenase; Belongs to the IMPDH/GMPR family.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	0.978

page 1 of 4

Server load: low (22%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Co-occurrence

Textmining

Co-expression

© STRING Consortium 2026

Credits

Access

Info

About