Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
F6PL99_CIOINAconitase domain-containing protein. (347 aa)    
Predicted Functional Partners:
H2XU13_CIOIN
Citrate synthase; Belongs to the citrate synthase family.
  
 0.985
F6SUS9_CIOIN
Isocitrate dehydrogenase [NAD] subunit, mitochondrial.
  
 0.977
LOC100178529
Malate dehydrogenase, mitochondrial-like; Belongs to the LDH/MDH superfamily.
  
 0.966
F6Z761_CIOIN
Uncharacterized protein.
  
 0.953
F6PL95_CIOIN
Uncharacterized protein.
 
     0.951
F6UHA9_CIOIN
2-oxogl_dehyd_N domain-containing protein.
  
 0.933
LOC100177133
ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.
  
 0.919
F6UTV1_CIOIN
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.
  
 0.912
F6ZF70_CIOIN
Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  
 0.899
H2XU53_CIOIN
Uncharacterized protein; Belongs to the heat shock protein 70 family.
   
 0.893
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt
Server load: low (16%) [HD]