Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
F6ZN89_CIOINUncharacterized protein; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (627 aa)    
Predicted Functional Partners:
H2XVZ6_CIOIN
Uncharacterized protein.
    
 
 0.990
LOC113474468
Replication protein A 14 kDa subunit-like.
    
 0.967
LOC100182514
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
    
 0.966
LOC100179894
Werner syndrome ATP-dependent helicase homolog isoform X1.
  
 
 0.922
LOC100184693
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.911
LOC100179683
26S proteasome non-ATPase regulatory subunit 14.
 
  
  0.892
H2Y379_CIOIN
RPA_C domain-containing protein.
   
 0.871
F6UM67_CIOIN
RING-type domain-containing protein.
    
 
 0.863
H2XKT2_CIOIN
3'-5' exonuclease domain-containing protein.
  
 
 0.853
LOC100180815
40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.
   
 0.846
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt
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