Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
F6ZV29_CIOINBTB domain-containing protein. (670 aa)    
Predicted Functional Partners:
LOC100186347
Phosphoribosyl pyrophosphate synthase-associated protein 2-like isoform X1.
    
 
 0.902
F6R472_CIOIN
CULLIN_2 domain-containing protein; Belongs to the cullin family.
    
 0.601
F6Z1B1_CIOIN
Uncharacterized protein.
  
 
  0.589
F6SM21_CIOIN
BTB domain-containing protein.
  
 
 
0.567
H2XUY6_CIOIN
Cullin_Nedd8 domain-containing protein; Belongs to the cullin family.
    
 0.516
H2Y2F9_CIOIN
Protein kinase domain-containing protein.
      
 0.513
F6V396_CIOIN
BTB domain-containing protein.
  
 
 
0.430
F6R5L0_CIOIN
Pribosyltran_N domain-containing protein.
    
 
 0.426
LOC100176189
E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
      
 0.421
LOC100176009
cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily.
    
  0.403
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt
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