Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
F6WUQ7_CIOINDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2157 aa)    
Predicted Functional Partners:
LOC100178968
DNA polymerase.
   
 0.999
F6WBW9_CIOIN
DNA_pol_E_B domain-containing protein.
   
 0.999
F7BPT5_CIOIN
CBFD_NFYB_HMF domain-containing protein.
    
 0.999
cbf-2
Transcription factor CBF/NF-Y/archaeal histone -2.
   
 0.999
LOC100184693
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
  
 0.995
F7BF26_CIOIN
Uncharacterized protein.
   
 0.990
LOC100176054
DNA primase; Belongs to the eukaryotic-type primase small subunit family.
   
 0.987
F6YH10_CIOIN
DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family.
   
 0.981
LOC100176589
DNA helicase; Belongs to the MCM family.
   
 0.980
F6RZM2_CIOIN
DNA polymerase.
   
 0.975
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.