F6PIW1_CIOIN protein (Ciona intestinalis) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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F6PIW1_CIOIN

Protein kinase domain-containing protein. (363 aa)

Predicted Functional Partners:

LOC100184552

0.646

LOC494376

0.646

LOC100185723

0.646

F6PQ89_CIOIN

0.646

H2XP64_CIOIN

0.641

Cam

0.616

LOC100181538

0.521

LOC100186781

0.503

LOC100178859

0.481

LOC100185594

0.451

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cam	F6PIW1_CIOIN	ENSCINP00000017572	ENSCINP00000020206	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Protein kinase domain-containing protein.	0.616
F6PIW1_CIOIN	Cam	ENSCINP00000020206	ENSCINP00000017572	Protein kinase domain-containing protein.	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	0.616
F6PIW1_CIOIN	F6PQ89_CIOIN	ENSCINP00000020206	ENSCINP00000025381	Protein kinase domain-containing protein.	Uncharacterized protein.	0.646
F6PIW1_CIOIN	H2XP64_CIOIN	ENSCINP00000020206	ENSCINP00000031447	Protein kinase domain-containing protein.	Uncharacterized protein.	0.641
F6PIW1_CIOIN	LOC100178859	ENSCINP00000020206	ENSCINP00000021258	Protein kinase domain-containing protein.	Calmodulin-2/4-like.	0.481
F6PIW1_CIOIN	LOC100181538	ENSCINP00000020206	ENSCINP00000012845	Protein kinase domain-containing protein.	Uncharacterized protein.	0.521
F6PIW1_CIOIN	LOC100184552	ENSCINP00000020206	ENSCINP00000001155	Protein kinase domain-containing protein.	Uncharacterized protein; Belongs to the calmodulin family.	0.646
F6PIW1_CIOIN	LOC100185594	ENSCINP00000020206	ENSCINP00000006322	Protein kinase domain-containing protein.	Spermatogenesis-associated protein 21-like.	0.451
F6PIW1_CIOIN	LOC100185723	ENSCINP00000020206	ENSCINP00000021608	Protein kinase domain-containing protein.	Calmodulin-2/4-like.	0.646
F6PIW1_CIOIN	LOC100186781	ENSCINP00000020206	ENSCINP00000035396	Protein kinase domain-containing protein.	Calmodulin-like protein 4.	0.503
F6PIW1_CIOIN	LOC494376	ENSCINP00000020206	ENSCINP00000015262	Protein kinase domain-containing protein.	Calmodulin-like.	0.646
F6PQ89_CIOIN	F6PIW1_CIOIN	ENSCINP00000025381	ENSCINP00000020206	Uncharacterized protein.	Protein kinase domain-containing protein.	0.646
H2XP64_CIOIN	F6PIW1_CIOIN	ENSCINP00000031447	ENSCINP00000020206	Uncharacterized protein.	Protein kinase domain-containing protein.	0.641
LOC100178859	F6PIW1_CIOIN	ENSCINP00000021258	ENSCINP00000020206	Calmodulin-2/4-like.	Protein kinase domain-containing protein.	0.481
LOC100181538	F6PIW1_CIOIN	ENSCINP00000012845	ENSCINP00000020206	Uncharacterized protein.	Protein kinase domain-containing protein.	0.521
LOC100184552	F6PIW1_CIOIN	ENSCINP00000001155	ENSCINP00000020206	Uncharacterized protein; Belongs to the calmodulin family.	Protein kinase domain-containing protein.	0.646
LOC100185594	F6PIW1_CIOIN	ENSCINP00000006322	ENSCINP00000020206	Spermatogenesis-associated protein 21-like.	Protein kinase domain-containing protein.	0.451
LOC100185723	F6PIW1_CIOIN	ENSCINP00000021608	ENSCINP00000020206	Calmodulin-2/4-like.	Protein kinase domain-containing protein.	0.646
LOC100186781	F6PIW1_CIOIN	ENSCINP00000035396	ENSCINP00000020206	Calmodulin-like protein 4.	Protein kinase domain-containing protein.	0.503
LOC494376	F6PIW1_CIOIN	ENSCINP00000015262	ENSCINP00000020206	Calmodulin-like.	Protein kinase domain-containing protein.	0.646

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.921

expected number of edges:

10

PPI enrichment p-value:

1.46e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016573

Histone acetylation

8 of 28

2.13

5.08

1.92e-12

GO:0043967

Histone H4 acetylation

5 of 8

2.47

4.13

8.49e-09

GO:0006325

Chromatin organization

10 of 238

1.29

2.05

3.53e-10

GO:0006974

Cellular response to DNA damage stimulus

10 of 278

1.23

1.82

1.28e-09

GO:0006281

DNA repair

9 of 230

1.26

1.81

1.73e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042393

Histone binding

4 of 51

1.56

0.96

0.0091

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035267

NuA4 histone acetyltransferase complex

11 of 18

2.46

10.04

2.20e-23

GO:0000118

Histone deacetylase complex

6 of 48

1.77

2.92

3.95e-08

GO:0000812

Swr1 complex

4 of 17

2.04

2.6

3.94e-06

GO:0000228

Nuclear chromosome

6 of 161

1.24

1.38

2.30e-05

GO:0000785

Chromatin

9 of 409

1.01

1.17

5.11e-07

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:19040720

(2008) Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment.

8 of 36

2.02

4.37

4.10e-11

PMID:37291101

(2023) A crucial role for dynamic expression of components encoding the negative arm of the circadian clock.

5 of 16

2.16

2.76

2.68e-06

PMID:30375921

(2019) Share and share alike: the role of Tra1 from the SAGA and NuA4 coactivator complexes.

5 of 16

2.16

2.76

2.68e-06

PMID:25849764

(2015) AtEAF1 is a potential platform protein for Arabidopsis NuA4 acetyltransferase complex.

4 of 7

2.43

2.53

1.61e-05

PMID:29626083

(2018) The Pseudokinase Domain of Saccharomyces cerevisiae Tra1 Is Required for Nuclear Localization and Incorporation into the SAGA and NuA4 Complexes.

3 of 18

1.89

0.78

0.0330

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4384

H4 histone acetyltransferase complex

9 of 10

2.62

8.85

8.07e-19

CL:4338

INO80-type complex, and H4 histone acetyltransferase complex

10 of 33

2.15

6.95

3.25e-18

CL:4336

ATPase complex, and Sin3-type complex

11 of 79

1.81

5.12

9.20e-18

CL:4387

Histone H2A acetylation, and YEATS family

4 of 5

2.57

3.47

2.62e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0035267

NuA4 histone acetyltransferase complex

11 of 14

2.56

10.88

2.46e-24

GOCC:0000118

Histone deacetylase complex

5 of 46

1.71

2.32

2.13e-06

GOCC:0000812

Swr1 complex

3 of 15

1.97

1.75

0.00030

GOCC:0000785

Chromatin

9 of 348

1.08

1.35

1.08e-07

GOCC:0070822

Sin3-type complex

2 of 15

1.79

0.9

0.0172

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0156

Chromatin regulator

10 of 104

1.65

3.75

6.64e-14

KW-0010

Activator

6 of 85

1.52

2.13

7.33e-07

KW-0227

DNA damage

7 of 158

1.32

1.74

7.33e-07

KW-0805

Transcription regulation

10 of 308

1.18

1.7

1.19e-09

KW-0234

DNA repair

6 of 129

1.34

1.62

6.51e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01408

Inhibitor of growth proteins N-terminal histone-binding

2 of 3

2.49

1.02

0.0135

SM00298

Chromatin organization modifier domain

2 of 9

2.02

0.77

0.0368

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