LOC100178053 protein (Ciona intestinalis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LOC100178053

Putative defense protein 3. (249 aa)

Predicted Functional Partners:

LOC100185062

0.590

F7BL09_CIOIN

0.577

LOC100175965

0.564

F6Q5I2_CIOIN

0.524

H2XPC5_CIOIN

0.524

F7APG8_CIOIN

0.521

H2XRJ8_CIOIN

0.518

F6R725_CIOIN

0.508

LOC100187383

0.506

LOC100184616

0.503

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6Q5I2_CIOIN	F6R725_CIOIN	ENSCINP00000001301	ENSCINP00000006378	Uncharacterized protein; Belongs to the universal ribosomal protein uS15 family.	Uncharacterized protein.	0.994
F6Q5I2_CIOIN	F7APG8_CIOIN	ENSCINP00000001301	ENSCINP00000027241	Uncharacterized protein; Belongs to the universal ribosomal protein uS15 family.	Uncharacterized protein.	0.998
F6Q5I2_CIOIN	F7BL09_CIOIN	ENSCINP00000001301	ENSCINP00000024710	Uncharacterized protein; Belongs to the universal ribosomal protein uS15 family.	Uncharacterized protein.	0.993
F6Q5I2_CIOIN	H2XPC5_CIOIN	ENSCINP00000001301	ENSCINP00000031508	Uncharacterized protein; Belongs to the universal ribosomal protein uS15 family.	Ribosomal_L16 domain-containing protein.	0.997
F6Q5I2_CIOIN	H2XRJ8_CIOIN	ENSCINP00000001301	ENSCINP00000032282	Uncharacterized protein; Belongs to the universal ribosomal protein uS15 family.	Uncharacterized protein; Belongs to the universal ribosomal protein uL22 family.	0.996
F6Q5I2_CIOIN	LOC100175965	ENSCINP00000001301	ENSCINP00000017144	Uncharacterized protein; Belongs to the universal ribosomal protein uS15 family.	39S ribosomal protein L3, mitochondrial-like.	0.995
F6Q5I2_CIOIN	LOC100178053	ENSCINP00000001301	ENSCINP00000023880	Uncharacterized protein; Belongs to the universal ribosomal protein uS15 family.	Putative defense protein 3.	0.524
F6Q5I2_CIOIN	LOC100184616	ENSCINP00000001301	ENSCINP00000008684	Uncharacterized protein; Belongs to the universal ribosomal protein uS15 family.	39S ribosomal protein L17, mitochondrial-like.	0.998
F6Q5I2_CIOIN	LOC100185062	ENSCINP00000001301	ENSCINP00000005704	Uncharacterized protein; Belongs to the universal ribosomal protein uS15 family.	39S ribosomal protein L23, mitochondrial-like.	0.820
F6Q5I2_CIOIN	LOC100187383	ENSCINP00000001301	ENSCINP00000011263	Uncharacterized protein; Belongs to the universal ribosomal protein uS15 family.	39S ribosomal protein L13, mitochondrial-like.	0.996
F6R725_CIOIN	F6Q5I2_CIOIN	ENSCINP00000006378	ENSCINP00000001301	Uncharacterized protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uS15 family.	0.994
F6R725_CIOIN	F7APG8_CIOIN	ENSCINP00000006378	ENSCINP00000027241	Uncharacterized protein.	Uncharacterized protein.	0.994
F6R725_CIOIN	F7BL09_CIOIN	ENSCINP00000006378	ENSCINP00000024710	Uncharacterized protein.	Uncharacterized protein.	0.985
F6R725_CIOIN	H2XPC5_CIOIN	ENSCINP00000006378	ENSCINP00000031508	Uncharacterized protein.	Ribosomal_L16 domain-containing protein.	0.992
F6R725_CIOIN	H2XRJ8_CIOIN	ENSCINP00000006378	ENSCINP00000032282	Uncharacterized protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uL22 family.	0.995
F6R725_CIOIN	LOC100175965	ENSCINP00000006378	ENSCINP00000017144	Uncharacterized protein.	39S ribosomal protein L3, mitochondrial-like.	0.994
F6R725_CIOIN	LOC100178053	ENSCINP00000006378	ENSCINP00000023880	Uncharacterized protein.	Putative defense protein 3.	0.508
F6R725_CIOIN	LOC100184616	ENSCINP00000006378	ENSCINP00000008684	Uncharacterized protein.	39S ribosomal protein L17, mitochondrial-like.	0.996
F6R725_CIOIN	LOC100185062	ENSCINP00000006378	ENSCINP00000005704	Uncharacterized protein.	39S ribosomal protein L23, mitochondrial-like.	0.577
F6R725_CIOIN	LOC100187383	ENSCINP00000006378	ENSCINP00000011263	Uncharacterized protein.	39S ribosomal protein L13, mitochondrial-like.	0.995

page 1 of 6

Network Stats

number of nodes:

10

number of edges:

39

average node degree:

7.8

avg. local clustering coefficient:

0.95

expected number of edges:

10

PPI enrichment p-value:

2.96e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006644

Phospholipid metabolic process

5 of 350

1.42

1.15

0.0016

GO:0019637

Organophosphate metabolic process

7 of 816

1.2

1.1

0.00043

GO:0016042

Lipid catabolic process

4 of 245

1.47

0.99

0.0063

GO:0006629

Lipid metabolic process

7 of 1093

1.07

0.87

0.0016

GO:0044255

Cellular lipid metabolic process

6 of 848

1.11

0.86

0.0030

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004623

Phospholipase A2 activity

4 of 40

2.26

2.59

8.53e-06

GO:0016788

Hydrolase activity, acting on ester bonds

8 of 813

1.25

1.54

2.90e-06

GO:0004528

Phosphodiesterase I activity

2 of 5

2.86

1.5

0.0019

GO:0004551

Nucleotide diphosphatase activity

2 of 15

2.39

1.09

0.0097

GO:0008081

Phosphoric diester hydrolase activity

3 of 103

1.73

1.07

0.0066

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:25342

Linoleic acid metabolism, and Glycerophospholipid catabolism

10 of 53

2.54

9.65

1.99e-21

CL:25343

Linoleic acid metabolism, and 1-alkyl-2-acetylglycerophosphocholine esterase complex

8 of 44

2.52

7.59

1.96e-16

CL:25345

Linoleic acid metabolism, and Synthesis of 15-eicosatetraenoic acid derivatives

6 of 33

2.52

5.48

1.37e-11

CL:25396

Phosphodiesterase I activity, and N-acylethanolamine metabolic process

3 of 5

3.04

2.92

4.78e-06

CL:25349

Mixed, incl. Icosanoid secretion, and Lipoxygenase

2 of 18

2.31

0.82

0.0309

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00565

Ether lipid metabolism

11 of 95

2.33

9.46

9.95e-24

map00592

alpha-Linolenic acid metabolism

6 of 43

2.41

5.45

6.77e-12

map00591

Linoleic acid metabolism

6 of 46

2.38

5.4

6.77e-12

map00590

Arachidonic acid metabolism

6 of 94

2.07

4.23

2.28e-10

map00564

Glycerophospholipid metabolism

7 of 207

1.79

3.57

2.17e-10

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1482788

Acyl chain remodelling of PC

4 of 42

2.24

2.5

1.29e-05

MAP-1483206

Glycerophospholipid biosynthesis

5 of 201

1.66

1.92

2.60e-05

MAP-1483257

Phospholipid metabolism

6 of 338

1.51

1.83

1.29e-05

MAP-1482839

Acyl chain remodelling of PE

3 of 43

2.11

1.61

0.00075

MAP-196843

Vitamin B2 (riboflavin) metabolism

2 of 12

2.48

1.22

0.0058

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01663

Type I phosphodiesterase / nucleotide pyrophosphatase

3 of 12

2.66

2.13

0.00012

PF06951

Group XII secretory phospholipase A2 precursor (PLA2G12)

2 of 3

3.09

1.4

0.0030

PF04970

Lecithin retinol acyltransferase

2 of 12

2.48

0.95

0.0181

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00201

Somatomedin B -like domains

2 of 8

2.66

1.13

0.0090

SM00477

DNA/RNA non-specific endonuclease

2 of 14

2.42

1.05

0.0120

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