STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC100182642Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (354 aa)    
Predicted Functional Partners:
LOC100177816
cyclin-H; Belongs to the cyclin family.
    
 0.971
zf(ring)-55
Zinc finger protein.
   
 0.971
LOC100184165
General transcription factor IIH subunit 3-like.
    
 0.967
Zf(c2h2)-114
General transcription factor IIH subunit.
   
 0.961
LOC100183594
General transcription and DNA repair factor IIH helicase subunit XPB.
    
 0.961
F6RMT1_CIOIN
Uncharacterized protein.
   
 0.960
LOC100177272
DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 0.933
F7BHW5_CIOIN
Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
   
 0.917
LOC100175005
HTH TFE/IIEalpha-type domain-containing protein.
    
 0.907
F6S7U3_CIOIN
General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family.
    
 0.889
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.