hvcn1 protein (Ciona intestinalis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

hvcn1

Voltage-gated hydrogen channel 1; Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity). (342 aa)

Predicted Functional Partners:

Vsp

0.581

F6QTW3_CIOIN

0.545

H2XSV6_CIOIN

0.524

F6PR01_CIOIN

0.484

H2Y2B7_CIOIN

0.463

Nox2

0.423

H2XM56_CIOIN

0.405

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6PR01_CIOIN	H2Y2B7_CIOIN	ENSCINP00000013096	ENSCINP00000036052	PKD_channel domain-containing protein.	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family.	0.672
F6PR01_CIOIN	hvcn1	ENSCINP00000013096	ENSCINP00000026518	PKD_channel domain-containing protein.	Voltage-gated hydrogen channel 1; Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity).	0.484
F6QTW3_CIOIN	hvcn1	ENSCINP00000016885	ENSCINP00000026518	Tyrosine-protein kinase.	Voltage-gated hydrogen channel 1; Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity).	0.545
H2XM56_CIOIN	hvcn1	ENSCINP00000030738	ENSCINP00000026518	CENP-F_N domain-containing protein.	Voltage-gated hydrogen channel 1; Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity).	0.405
H2XSV6_CIOIN	hvcn1	ENSCINP00000032740	ENSCINP00000026518	Hyaluronidase.	Voltage-gated hydrogen channel 1; Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity).	0.524
H2Y2B7_CIOIN	F6PR01_CIOIN	ENSCINP00000036052	ENSCINP00000013096	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family.	PKD_channel domain-containing protein.	0.672
H2Y2B7_CIOIN	hvcn1	ENSCINP00000036052	ENSCINP00000026518	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family.	Voltage-gated hydrogen channel 1; Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity).	0.463
Nox2	hvcn1	ENSCINP00000008272	ENSCINP00000026518	FAD-binding FR-type domain-containing protein.	Voltage-gated hydrogen channel 1; Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity).	0.423
Vsp	hvcn1	ENSCINP00000021926	ENSCINP00000026518	Uncharacterized protein.	Voltage-gated hydrogen channel 1; Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity).	0.581
hvcn1	F6PR01_CIOIN	ENSCINP00000026518	ENSCINP00000013096	Voltage-gated hydrogen channel 1; Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity).	PKD_channel domain-containing protein.	0.484
hvcn1	F6QTW3_CIOIN	ENSCINP00000026518	ENSCINP00000016885	Voltage-gated hydrogen channel 1; Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity).	Tyrosine-protein kinase.	0.545
hvcn1	H2XM56_CIOIN	ENSCINP00000026518	ENSCINP00000030738	Voltage-gated hydrogen channel 1; Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity).	CENP-F_N domain-containing protein.	0.405
hvcn1	H2XSV6_CIOIN	ENSCINP00000026518	ENSCINP00000032740	Voltage-gated hydrogen channel 1; Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity).	Hyaluronidase.	0.524
hvcn1	H2Y2B7_CIOIN	ENSCINP00000026518	ENSCINP00000036052	Voltage-gated hydrogen channel 1; Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity).	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family.	0.463
hvcn1	Nox2	ENSCINP00000026518	ENSCINP00000008272	Voltage-gated hydrogen channel 1; Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity).	FAD-binding FR-type domain-containing protein.	0.423
hvcn1	Vsp	ENSCINP00000026518	ENSCINP00000021926	Voltage-gated hydrogen channel 1; Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity).	Uncharacterized protein.	0.581

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.841

expected number of edges:

16

PPI enrichment p-value:

7.42e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006783

Heme biosynthetic process

3 of 13

1.97

1.51

0.0010

GO:0045333

Cellular respiration

3 of 47

1.41

0.82

0.0155

GO:0006119

Oxidative phosphorylation

2 of 11

1.86

0.8

0.0292

GO:0022904

Respiratory electron transport chain

2 of 15

1.73

0.68

0.0473

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015453

Oxidoreduction-driven active transmembrane transporter activity

5 of 19

2.02

2.81

1.06e-06

GO:0015078

Proton transmembrane transporter activity

5 of 19

2.02

2.81

1.06e-06

GO:0022853

Active ion transmembrane transporter activity

5 of 37

1.73

2.2

6.94e-06

GO:0004129

Cytochrome-c oxidase activity

3 of 5

2.38

2.19

7.10e-05

GO:0009055

Electron transfer activity

5 of 41

1.69

2.12

8.35e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070469

Respirasome

3 of 9

2.13

1.78

0.00034

GO:0016021

Integral component of membrane

8 of 885

0.56

0.38

0.0166

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3096

Mixed, incl. Cytochrome-c oxidase activity, and RDD family

7 of 11

2.41

5.72

1.63e-12

CL:3098

Cytochrome-c oxidase activity, and Rieske iron-sulphur protein

4 of 6

2.43

3.22

6.34e-07

CL:2786

Mixed, incl. Tetrapyrrole biosynthetic process, and Oxidative phosphorylation

9 of 198

1.26

1.83

1.17e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

7 of 58

1.69

2.98

4.33e-09

map00860

Porphyrin and chlorophyll metabolism

4 of 61

1.42

1.24

0.00084

map01100

Metabolic pathways

10 of 1709

0.37

0.28

0.0236

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070469

Respirasome

3 of 14

1.94

1.33

0.0024

GOCC:0005739

Mitochondrion

3 of 50

1.38

0.66

0.0392

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0249

Electron transport

4 of 7

2.36

3.0

1.51e-06

KW-0679

Respiratory chain

3 of 3

2.6

2.47

2.55e-05

KW-0408

Iron

5 of 68

1.47

1.67

3.38e-05

KW-0350

Heme biosynthesis

2 of 2

2.6

1.54

0.0015

KW-0186

Copper

2 of 3

2.43

1.45

0.0021

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (30%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About