Zf(phd)-26 protein (Ciona intestinalis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

Zf(phd)-26

PHD-type domain-containing protein. (257 aa)

Predicted Functional Partners:

F6XT34_CIOIN

0.657

F6U2A4_CIOIN

0.638

F6UK15_CIOIN

0.625

F6PHE6_CIOIN

0.621

LOC100185398

0.562

H2XVM9_CIOIN

0.553

F6PM34_CIOIN

0.539

H2Y3B8_CIOIN

0.501

F6YSI2_CIOIN

0.484

F6Y9A9_CIOIN

0.484

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6PHE6_CIOIN	F6PM34_CIOIN	ENSCINP00000018285	ENSCINP00000009862	Uncharacterized protein.	Bromo domain-containing protein.	0.877
F6PHE6_CIOIN	F6U2A4_CIOIN	ENSCINP00000018285	ENSCINP00000009518	Uncharacterized protein.	BAF250_C domain-containing protein.	0.982
F6PHE6_CIOIN	F6UK15_CIOIN	ENSCINP00000018285	ENSCINP00000003409	Uncharacterized protein.	SWIB domain-containing protein.	0.996
F6PHE6_CIOIN	F6XT34_CIOIN	ENSCINP00000018285	ENSCINP00000015936	Uncharacterized protein.	HMG box domain-containing protein.	0.990
F6PHE6_CIOIN	F6Y9A9_CIOIN	ENSCINP00000018285	ENSCINP00000007355	Uncharacterized protein.	Uncharacterized protein.	0.928
F6PHE6_CIOIN	F6YSI2_CIOIN	ENSCINP00000018285	ENSCINP00000007347	Uncharacterized protein.	Uncharacterized protein.	0.928
F6PHE6_CIOIN	H2XVM9_CIOIN	ENSCINP00000018285	ENSCINP00000033713	Uncharacterized protein.	Uncharacterized protein.	0.999
F6PHE6_CIOIN	H2Y3B8_CIOIN	ENSCINP00000018285	ENSCINP00000036403	Uncharacterized protein.	Uncharacterized protein.	0.583
F6PHE6_CIOIN	LOC100185398	ENSCINP00000018285	ENSCINP00000010732	Uncharacterized protein.	Actin-like protein 6B; Belongs to the actin family.	0.996
F6PHE6_CIOIN	Zf(phd)-26	ENSCINP00000018285	ENSCINP00000029150	Uncharacterized protein.	PHD-type domain-containing protein.	0.621
F6PM34_CIOIN	F6PHE6_CIOIN	ENSCINP00000009862	ENSCINP00000018285	Bromo domain-containing protein.	Uncharacterized protein.	0.877
F6PM34_CIOIN	F6U2A4_CIOIN	ENSCINP00000009862	ENSCINP00000009518	Bromo domain-containing protein.	BAF250_C domain-containing protein.	0.527
F6PM34_CIOIN	F6UK15_CIOIN	ENSCINP00000009862	ENSCINP00000003409	Bromo domain-containing protein.	SWIB domain-containing protein.	0.890
F6PM34_CIOIN	F6XT34_CIOIN	ENSCINP00000009862	ENSCINP00000015936	Bromo domain-containing protein.	HMG box domain-containing protein.	0.924
F6PM34_CIOIN	F6Y9A9_CIOIN	ENSCINP00000009862	ENSCINP00000007355	Bromo domain-containing protein.	Uncharacterized protein.	0.774
F6PM34_CIOIN	F6YSI2_CIOIN	ENSCINP00000009862	ENSCINP00000007347	Bromo domain-containing protein.	Uncharacterized protein.	0.774
F6PM34_CIOIN	H2XVM9_CIOIN	ENSCINP00000009862	ENSCINP00000033713	Bromo domain-containing protein.	Uncharacterized protein.	0.923
F6PM34_CIOIN	H2Y3B8_CIOIN	ENSCINP00000009862	ENSCINP00000036403	Bromo domain-containing protein.	Uncharacterized protein.	0.543
F6PM34_CIOIN	LOC100185398	ENSCINP00000009862	ENSCINP00000010732	Bromo domain-containing protein.	Actin-like protein 6B; Belongs to the actin family.	0.774
F6PM34_CIOIN	Zf(phd)-26	ENSCINP00000009862	ENSCINP00000029150	Bromo domain-containing protein.	PHD-type domain-containing protein.	0.539

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.884

expected number of edges:

11

PPI enrichment p-value:

0.00635

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006171

cAMP biosynthetic process

4 of 16

2.81

3.57

2.47e-07

GO:0048015

Phosphatidylinositol-mediated signaling

4 of 62

2.22

2.64

6.08e-06

GO:0007186

G protein-coupled receptor signaling pathway

11 of 1158

1.39

2.5

4.91e-12

GO:0019637

Organophosphate metabolic process

8 of 857

1.38

1.92

3.17e-07

GO:0007189

Adenylate cyclase-activating G protein-coupled receptor signaling pathway

4 of 158

1.81

1.78

0.00016

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004016

Adenylate cyclase activity

4 of 14

2.86

3.78

1.04e-07

GO:0004435

Phosphatidylinositol phospholipase C activity

4 of 22

2.67

3.52

2.53e-07

GO:0046935

1-phosphatidylinositol-3-kinase regulator activity

2 of 24

2.33

1.06

0.0110

GO:0005509

Calcium ion binding

4 of 822

1.1

0.58

0.0370

GO:0046872

Metal ion binding

8 of 4917

0.62

0.41

0.0180

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005944

Phosphatidylinositol 3-kinase complex, class IB

2 of 5

3.01

1.35

0.0037

GO:0019898

Extrinsic component of membrane

3 of 295

1.42

0.64

0.0459

GO:0016020

Membrane

11 of 10836

0.41

0.31

0.0116

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36552321

(2022) Chromosome-Level Genome Assembly of the Speckled Blue Grouper (Epinephelus cyanopodus) Provides Insight into Its Adaptive Evolution.

3 of 17

2.65

1.97

0.00024

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:41009

Mixed, incl. G alpha (z) signalling events, and G-protein beta/gamma-subunit complex binding

10 of 86

2.47

9.18

8.30e-21

CL:41015

G alpha (z) signalling events, and Phosphatidylinositol 3-kinase complex, class IB

7 of 44

2.61

6.93

1.58e-14

CL:41017

G alpha (z) signalling events, and G-protein alpha subunit, group S

4 of 26

2.6

3.52

2.20e-07

CL:41143

Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion

3 of 6

3.11

3.14

1.95e-06

CL:41079

Mixed, incl. Phosphatidylinositol 3-kinase complex, class IB, and Guanine nucleotide-binding protein, beta subunit

3 of 12

2.81

2.73

9.68e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

onl04371

Apelin signaling pathway

11 of 160

2.25

8.79

4.97e-23

onl04261

Adrenergic signaling in cardiomyocytes

10 of 194

2.12

7.08

2.90e-19

onl04540

Gap junction

8 of 101

2.31

6.9

3.51e-16

onl04912

GnRH signaling pathway

8 of 104

2.29

6.86

3.51e-16

onl04916

Melanogenesis

8 of 125

2.21

6.43

1.08e-15

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-112043

PLC beta mediated events

8 of 56

2.56

7.9

6.19e-17

MAP-112040

G-protein mediated events

8 of 66

2.49

7.58

1.40e-16

MAP-111885

Opioid Signalling

9 of 113

2.31

7.26

3.63e-17

MAP-397795

G-protein beta:gamma signalling

7 of 54

2.52

6.72

2.14e-14

MAP-112314

Neurotransmitter receptors and postsynaptic signal transmission

9 of 293

1.9

4.83

3.00e-14

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005944

Phosphatidylinositol 3-kinase complex, class IB

2 of 8

2.81

1.11

0.0096

GOCC:0019898

Extrinsic component of membrane

3 of 144

1.73

0.97

0.0115

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0442

Lipid degradation

4 of 46

2.35

3.09

9.52e-07

KW-0115

cAMP biosynthesis

3 of 13

2.77

3.0

2.93e-06

KW-0456

Lyase

4 of 74

2.14

2.73

2.93e-06

KW-0464

Manganese

3 of 74

2.02

1.87

0.00018

KW-0807

Transducer

5 of 524

1.39

1.5

6.40e-05

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08703

PLC-beta C terminal

4 of 4

3.41

4.79

2.10e-09

PF06631

Protein of unknown function (DUF1154)

3 of 4

3.28

3.17

1.84e-06

PF09279

Phosphoinositide-specific phospholipase C, efhand-like

3 of 12

2.81

2.61

1.60e-05

PF10486

Phosphoinositide 3-kinase gamma adapter protein p101 subunit

2 of 4

3.11

1.62

0.0012

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR014815

Phospholipase C-beta, C-terminal domain

4 of 4

3.41

4.57

5.37e-09

IPR042531

Phospholipase C-beta, C-terminal domain superfamily

4 of 5

3.31

4.56

5.37e-09

IPR037862

PLC-beta, PH domain

4 of 5

3.31

4.56

5.37e-09

IPR016280

Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta

4 of 5

3.31

4.56

5.37e-09

IPR001711

Phospholipase C, phosphatidylinositol-specific, Y domain

4 of 23

2.65

3.5

2.68e-07

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00149

Phospholipase C, catalytic domain (part)

4 of 23

2.65

3.59

1.77e-07

SM00148

Phospholipase C, catalytic domain (part)

4 of 23

2.65

3.59

1.77e-07

SM00044

Adenylyl- / guanylyl cyclase, catalytic domain

4 of 32

2.5

3.5

1.98e-07

SM00239

Protein kinase C conserved region 2 (CalB)

4 of 200

1.71

1.69

0.00017

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